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기관지천식 환자에서 혈중 eosinophil cationic protein의 임상적 의의
DC Field | Value | Language |
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dc.contributor.author | 박중원 | - |
dc.contributor.author | 홍천수 | - |
dc.date.accessioned | 2020-07-02T17:23:31Z | - |
dc.date.available | 2020-07-02T17:23:31Z | - |
dc.date.issued | 1998 | - |
dc.identifier.issn | 1226-8739 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/176783 | - |
dc.description.abstract | Objective : The aim of this study was to investigate the usefulness of serum ECP as a marker of the severity of asthma and extent of airway inflammation. Methods : We investigated 108 patients suffering from bronchial asthma, who were classified as mild intermittent(n=19), mild persistent(n=27), moderate persistent(n=42), and severe persistent(n=20) and 10 healthy controls. Atopy was defined as those who showed >2+ responses on skin prick test. Serum ECP, peripheral blood eosinophil, sputum eosinophil, and PEFR were measured on the same date and methacholine PC20 were determined within 2 weeks. Results : Serum ECP levels were 10.1±2.0ug/L in controls, and 29.1±23.6ug/L in asthmatic patients. According to symptom severity, serum ECP levels were 22.9± 15.6ug/L, 28.6±24.1ug/L, 29.5± 22.2ug/L, and 34.6±31.2ug/L in mild intermittent, mild persistent, moderate persistent and severe persistent asthmatic patients, respectively and there were no significant differences among four groups(p>0.05), Serum ECP levels correlated with peripheral blood eosinophil counts(r=0.48, p<0.01), but not with sputum eosinophil, PEFR, and methacholine PC20 levels. There was no significant difference in serum ECP level between atopic and non-atopic asthma(p>0.05). Conclusion : Single measurement of ECP level at clinic could not represent the severity of asthma. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English, Korean | - |
dc.publisher | 대한천식알레르기학회 | - |
dc.relation.isPartOf | Journal of Asthma, Allergy and Clinical Immunology (천식 및 알레르기) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | 기관지천식 환자에서 혈중 eosinophil cationic protein의 임상적 의의 | - |
dc.title.alternative | Clinical significance of eosinophil cationic protein(ECP) in bronchial asthma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | 윤영연 | - |
dc.contributor.googleauthor | 박중원 | - |
dc.contributor.googleauthor | 홍천수 | - |
dc.contributor.localId | A01681 | - |
dc.contributor.localId | A04448-1 | - |
dc.relation.journalcode | J01251 | - |
dc.contributor.alternativeName | Park, Jung Won | - |
dc.contributor.affiliatedAuthor | 박중원 | - |
dc.contributor.affiliatedAuthor | 홍천수 | - |
dc.citation.volume | 18 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 681 | - |
dc.citation.endPage | 688 | - |
dc.identifier.bibliographicCitation | Journal of Asthma, Allergy and Clinical Immunology (천식 및 알레르기), Vol.18(4) : 681-688, 1998 | - |
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