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유방암 진행에 따른 Telomerase Activity 발현 증가
DC Field | Value | Language |
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dc.contributor.author | 노재경 | - |
dc.contributor.author | 정현철 | - |
dc.date.accessioned | 2020-07-02T17:14:11Z | - |
dc.date.available | 2020-07-02T17:14:11Z | - |
dc.date.issued | 1997 | - |
dc.identifier.issn | 0496-6872 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/176687 | - |
dc.description.abstract | PURPOSE: We studied the telomerase activity in normal and cancer tissues of the breast and then compared it to the clinical parameters. MATERIALS AND METHODS: 36 paired normal and cancerous breast tissues were assayed for telomerase activity by PCR-based TRAP assay (telomeric repeat amplification protocol). In 17 cancer tissues, flow cytometric analysis for S-phase fraction was done. RESULTS: None of the normal breast tissue expressed telomerase activity while 23 out of 26 breast cancer tissue expressed telomerase activity (92%). Clinical parameters such as T-factor, tumor grade, hormone receptor expression, mitosis, S-phase fraction did not correlate with telomerase expression. However, telomerase acitvity increased with cancer progression such as; in a state of lymph node metastasis and in an advanced pathological stage. CONCLUSION: Telomerase activity was expressed only from cancer tissues. And this expression increased with cancer progression suggesting a possible therapeutic target in breast cancer. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean | - |
dc.publisher | 대한암학회 | - |
dc.relation.isPartOf | Journal of the Korean Cancer Association (대한암학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | 유방암 진행에 따른 Telomerase Activity 발현 증가 | - |
dc.title.alternative | Increment of Telomerase Activity with Breast Cancer Progression | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | 박규현 | - |
dc.contributor.googleauthor | 라선영 | - |
dc.contributor.googleauthor | 김태수 | - |
dc.contributor.googleauthor | 이병찬 | - |
dc.contributor.googleauthor | 박세호 | - |
dc.contributor.googleauthor | 정현철 | - |
dc.contributor.googleauthor | 이원영 | - |
dc.contributor.googleauthor | 김주항 | - |
dc.contributor.googleauthor | 노재경 | - |
dc.contributor.googleauthor | 이경식 | - |
dc.contributor.googleauthor | 민진식 | - |
dc.contributor.googleauthor | 김병수 | - |
dc.contributor.localId | A01290 | - |
dc.contributor.localId | A03773 | - |
dc.relation.journalcode | J01813 | - |
dc.subject.keyword | Breast cancer | - |
dc.subject.keyword | Telomerase | - |
dc.contributor.alternativeName | Roh, Jae Kyung | - |
dc.contributor.affiliatedAuthor | 노재경 | - |
dc.contributor.affiliatedAuthor | 정현철 | - |
dc.citation.volume | 29 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1032 | - |
dc.citation.endPage | 1040 | - |
dc.identifier.bibliographicCitation | Journal of the Korean Cancer Association (대한암학회지), Vol.29(6) : 1032-1040, 1997 | - |
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