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Acute effects of recombinant human erythropoietin on plasma levels of proendothelin-1 and endothelin-1 in haemodialysis patients.

DC FieldValueLanguage
dc.contributor.author한대석-
dc.date.accessioned2020-07-02T17:07:48Z-
dc.date.available2020-07-02T17:07:48Z-
dc.date.issued1998-
dc.identifier.issn0931-0509-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/176612-
dc.description.abstractBACKGROUND: The pathogenesis of rHuEpo-induced hypertension in haemodialysis (HD) patients still remains uncertain. Endothelin-1 (ET-1) is produced from proendothelin-1 (proET-1) by an endothelin-converting enzyme. Since proET-1 is known to have approximately 1/100 the potency of ET-1 for contracting an isolated blood vessel, the change in the activity of endothelin-converting enzyme (ECE) has been proposed as an important factor in the pathophysiology of various hypertensive diseases. However there is no report on whether a change in the rate of conversion of proET-1 to ET-1 may be involved in the pathogenesis of rHuEpo-induced hypertension. The purpose of this study was to ascertain the potential role of ECE in the development of rHuEpo-induced hypertension. METHODS: The levels of plasma erythropoietin, proET-1, ET-1, and mean arterial blood pressure (MAP) were measured following a single dose of rHuEpo (100 U/kg) in HD patients with 24-h ambulatory blood pressure monitoring. Different routes of administration (19 intravenous group, 10 subcutaneous group) were compared to a placebo-injected control group (10 HD patients). RESULTS: Plasma erythropoietin levels reached maximal value 5 min after i.v. injection of rHuEpo (13.1+/-2.4 vs 2780.9+/-290.1 mU/ml, P<0.01), whereas it was 6 h in the s.c. group (14.7+/-3.8 vs 38.9+/-17.7 mU/ml, P<0.05). A significant increase in MAP was noted 30 min after rHuEpo injection, which lasted for 3 h in the i.v. group. However, no significant changes in MAP were noted in patients given rHuEpo subcutaneously. Both the plasma concentrations of proET-1 and ET-1 started to increase from 10 min after i.v. rHuEpo administration, with the proET-1 reaching a peak level at 30 min (13.5+/-7.4 vs 21.6+/-3.8 pg/ml, P<0.05) and the ET-1 at 1 h (4.2+/-2.6 vs 9.9+/-4.8 pg/ml, P<0.05). In patients with significant interdialysis hypertension following a single i.v. injection of rHuEpo, the molar ratio of ET-1 over proET-1 (ET-1/proET-1) was significantly higher than in patients without hypertension. In addition, the increase in ET-1 levels was significantly greater in patients with interdialysis hypertension, while changes in proET-1 level were similar in both hypertensive and non-hypertensive groups. Changes in interdialysis MAP (delta IDMAP) was significantly correlated with delta ET-1 during the interdialysis period, but not with delta proET-1. CONCLUSION: Differences in ET-1/proET-1 ratio in relation to changes in MAP after a single intravenous administration of rHuEpo suggest a potential role for ECE in the pathogenesis of rHuEpo-induced hypertension.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherOxford University Press-
dc.relation.isPartOfNEPHROLOGY DIALYSIS TRANSPLANTATION-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHBlood Pressure/drug effects-
dc.subject.MESHEndothelin-1/blood*-
dc.subject.MESHEndothelins/blood*-
dc.subject.MESHErythropoietin/blood-
dc.subject.MESHErythropoietin/pharmacology*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHProtein Precursors/blood*-
dc.subject.MESHRecombinant Proteins-
dc.subject.MESHRenal Dialysis*-
dc.titleAcute effects of recombinant human erythropoietin on plasma levels of proendothelin-1 and endothelin-1 in haemodialysis patients.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorDuk-Hee Kang-
dc.contributor.googleauthorKyun-Il Yoon-
dc.contributor.googleauthorDae-Suk Han-
dc.identifier.doi10.1093/ndt/13.11.2877-
dc.contributor.localIdA04272-
dc.relation.journalcodeJ02316-
dc.identifier.eissn1460-2385-
dc.identifier.pmid9829494-
dc.contributor.alternativeNameHan, Dae Suk-
dc.contributor.affiliatedAuthor한대석-
dc.citation.volume13-
dc.citation.number11-
dc.citation.startPage2877-
dc.citation.endPage2883-
dc.identifier.bibliographicCitationNEPHROLOGY DIALYSIS TRANSPLANTATION, Vol.13(11) : 2877-2883, 1998-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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