Cited 49 times in
Acute effects of recombinant human erythropoietin on plasma levels of proendothelin-1 and endothelin-1 in haemodialysis patients.
DC Field | Value | Language |
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dc.contributor.author | 한대석 | - |
dc.date.accessioned | 2020-07-02T17:07:48Z | - |
dc.date.available | 2020-07-02T17:07:48Z | - |
dc.date.issued | 1998 | - |
dc.identifier.issn | 0931-0509 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/176612 | - |
dc.description.abstract | BACKGROUND: The pathogenesis of rHuEpo-induced hypertension in haemodialysis (HD) patients still remains uncertain. Endothelin-1 (ET-1) is produced from proendothelin-1 (proET-1) by an endothelin-converting enzyme. Since proET-1 is known to have approximately 1/100 the potency of ET-1 for contracting an isolated blood vessel, the change in the activity of endothelin-converting enzyme (ECE) has been proposed as an important factor in the pathophysiology of various hypertensive diseases. However there is no report on whether a change in the rate of conversion of proET-1 to ET-1 may be involved in the pathogenesis of rHuEpo-induced hypertension. The purpose of this study was to ascertain the potential role of ECE in the development of rHuEpo-induced hypertension. METHODS: The levels of plasma erythropoietin, proET-1, ET-1, and mean arterial blood pressure (MAP) were measured following a single dose of rHuEpo (100 U/kg) in HD patients with 24-h ambulatory blood pressure monitoring. Different routes of administration (19 intravenous group, 10 subcutaneous group) were compared to a placebo-injected control group (10 HD patients). RESULTS: Plasma erythropoietin levels reached maximal value 5 min after i.v. injection of rHuEpo (13.1+/-2.4 vs 2780.9+/-290.1 mU/ml, P<0.01), whereas it was 6 h in the s.c. group (14.7+/-3.8 vs 38.9+/-17.7 mU/ml, P<0.05). A significant increase in MAP was noted 30 min after rHuEpo injection, which lasted for 3 h in the i.v. group. However, no significant changes in MAP were noted in patients given rHuEpo subcutaneously. Both the plasma concentrations of proET-1 and ET-1 started to increase from 10 min after i.v. rHuEpo administration, with the proET-1 reaching a peak level at 30 min (13.5+/-7.4 vs 21.6+/-3.8 pg/ml, P<0.05) and the ET-1 at 1 h (4.2+/-2.6 vs 9.9+/-4.8 pg/ml, P<0.05). In patients with significant interdialysis hypertension following a single i.v. injection of rHuEpo, the molar ratio of ET-1 over proET-1 (ET-1/proET-1) was significantly higher than in patients without hypertension. In addition, the increase in ET-1 levels was significantly greater in patients with interdialysis hypertension, while changes in proET-1 level were similar in both hypertensive and non-hypertensive groups. Changes in interdialysis MAP (delta IDMAP) was significantly correlated with delta ET-1 during the interdialysis period, but not with delta proET-1. CONCLUSION: Differences in ET-1/proET-1 ratio in relation to changes in MAP after a single intravenous administration of rHuEpo suggest a potential role for ECE in the pathogenesis of rHuEpo-induced hypertension. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Oxford University Press | - |
dc.relation.isPartOf | NEPHROLOGY DIALYSIS TRANSPLANTATION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Blood Pressure/drug effects | - |
dc.subject.MESH | Endothelin-1/blood* | - |
dc.subject.MESH | Endothelins/blood* | - |
dc.subject.MESH | Erythropoietin/blood | - |
dc.subject.MESH | Erythropoietin/pharmacology* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Protein Precursors/blood* | - |
dc.subject.MESH | Recombinant Proteins | - |
dc.subject.MESH | Renal Dialysis* | - |
dc.title | Acute effects of recombinant human erythropoietin on plasma levels of proendothelin-1 and endothelin-1 in haemodialysis patients. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Duk-Hee Kang | - |
dc.contributor.googleauthor | Kyun-Il Yoon | - |
dc.contributor.googleauthor | Dae-Suk Han | - |
dc.identifier.doi | 10.1093/ndt/13.11.2877 | - |
dc.contributor.localId | A04272 | - |
dc.relation.journalcode | J02316 | - |
dc.identifier.eissn | 1460-2385 | - |
dc.identifier.pmid | 9829494 | - |
dc.contributor.alternativeName | Han, Dae Suk | - |
dc.contributor.affiliatedAuthor | 한대석 | - |
dc.citation.volume | 13 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 2877 | - |
dc.citation.endPage | 2883 | - |
dc.identifier.bibliographicCitation | NEPHROLOGY DIALYSIS TRANSPLANTATION, Vol.13(11) : 2877-2883, 1998 | - |
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