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폐쇄성 황달 및 급성 담도염 환자에서 단기간의 담즙 배액이 혈청 및 담즙의 Carcinoembryonic Antigen과 CA19-9월 진단적 가치에 미치는 영향

Other Titles
 Effect of Biliary Drainage on the Diagnostic Values of Serum and Bile CEA and CA19-9 in Patients with Obstructive Jaundice anchor Acute Cholangitis 
 조현근  ;  정준표  ;  박효진  ;  이관식  ;  정재복  ;  전재윤  ;  이상인  ;  문영명  ;  강진경 
 Korean Journal of Gastroenterology (대한소화기학회지), Vol.32(6) : 792-801, 1998 
Journal Title
 Korean Journal of Gastroenterology (대한소화기학회지) 
Issue Date
Background/Aims : It is controversial to use serum cartinoembryonic antigen (CEA), serum CA 19-9, bile CEA, and bile CA19-9 in diagnosing malignant pancreaticobiliary diseases. The aim of this study was to determine whether a short-term biliary drainage affects the values of serum CEA, serum CA19-9, bile CEA, and bile CA19-9 and thus, improves diagnostic values. Methods : Thirteen patients with benign causes of obstructive jaundice and/or acute cholangitis and 24 patients with malignant causes were examined. All patients underwent endoscopic or percutaneous biliary drainage. Serum and bile samples were obtained at the time of biliary drainage procedure and at 2 and 7 days of post-drainage. Then, the values of CEA and CA19-9 were measured. Results : Biliary drainage did not change serum CEA in benign and malignant diseases. The specificity and positive predictive value (PPV) of serum CEA were increased after drainage, whereas its sensitivity, negative predictive value (NPV), and accuracy were decreased. Serum CA19-9 was significantly decreased at 7 days of post-drainage in benign diseases (p=0.0018). The specificity, PPV, NPV, and accuracy of serum CA 19-9 increased after drainage, whereas its sensitivity was decreased. The values of bile CEA and CA19-9 were not affected by ciliary drainage and showed no difference between benign and malignant diseases. Conclusions : Biliary drainage affects the diagnostic valves of serum CEA and CA19-9. Bile CEA and CA19-9 have no diagnostic roles.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Kwan Sik(이관식) ORCID logo https://orcid.org/0000-0002-3672-1198
Chung, Jae Bock(정재복)
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