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Helicobacter pylori 감염과 세포증식 및 세포사멸간의 관계

Other Titles
 Relation of Apoytosis and Cell Proliferation in Helicobactor pylori Infection 
 정상수  ;  박인서  ;  이상인  ;  이관식  ;  정병천  ;  박효진  ;  채보원 
 Korean Journal of Gastroenterology (대한소화기학회지), Vol.32(4) : 427-434, 1998 
Journal Title
 Korean Journal of Gastroenterology (대한소화기학회지) 
Issue Date
Background/Aims: Many studies have shown that Helicobacter pylori (H. pylori) infection is associated with gastroduodenal diseases. The pathogenic effects of H. pylori are associated with cytokine production, cell cycle progression, cellular proliferation and apoptosis. We performed this study to investigate the effect of H. pylori eradication on gastric mucosal cell apoptosis and proliferation. Methods: Gastroduodenoscopy was performed for 42 cases. Twenty two of them showed H. pylori-positive gastritis and the other 20 cases showed H. pylori-negative normal mucosa. H. pylori infection was assessed by rapid urease test and histology of biopsy specimens from gastric antrum. Ki-67 immunostaining of gastric biopsy specimens was used to measure mucosal cell proliferation in H. pylori positive gastritis before and after therapy. DNA frapnentation with terminal deoxynu- cleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling method was used for a marker of apoptosis. Results: Apoptosis was increased in gastric mucosal epithelium of patients with H. pylori-positive gastritis (p<0.05). H. pylori eradication therapy reduced apoptosis in antral mucosa (p<0.05) and the cell proliferation levels (p=0.051). Conclusions: Induction of apoptosis in gastric epithelium by chronic stimulation of H. pylori could be involved in the pathogenesis of gastroduodenal diseases.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Hyo Jin(박효진) ORCID logo https://orcid.org/0000-0003-4814-8330
Lee, Kwan Sik(이관식) ORCID logo https://orcid.org/0000-0002-3672-1198
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