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방사선의 항암작용에 대한 재조합 TNF-α의 효과
DC Field | Value | Language |
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dc.contributor.author | 성진실 | - |
dc.date.accessioned | 2020-07-02T17:02:23Z | - |
dc.date.available | 2020-07-02T17:02:23Z | - |
dc.date.issued | 1998 | - |
dc.identifier.issn | 1229-8719 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/176545 | - |
dc.description.abstract | Purpose : To determine whether TNF-α increases the antitumor effect of radiotherapy in murine syngeneic tumor system. Materials and Methods : Syngeneic murine tumors of MCa-K or MCa-4 (mammary carcinoma), OCa-I (ovarian carcinoma), or HCa-I(hepatocarcinoma were grown in hind legs of C3Hf/HeJ mice. When tumors were grown to 6 mm in mean diameter mice were treated with TNF-α, radiation, or combination of the both. Gamma-radiation was given as a single dose of 30 Gy for HCa-I and 15 Gy for other tumors using Cobalt-60 teletherapy unit. A novel TNF-α mutein developed in Korea, was intraperitoneally administered daily at a dose of 10 ug per mouse for 7 days. In combination of radiation and TNF-α, the drug was started 1 hour after radiation. Tumor growth delay assay was used to measure the tumor response to the treatment. Results : Among 4 tested tumors, TNF-α alone showed significant antitumor activity in MCa-K and OCa-I tumors, which showed absolute growth delay (AGD) of 5.0 days and 6.5 days, respectively. In combination with radiation, TNF-α showed significant delay of AGD (41.1 days) in OCA-I compared to AGDs of TNF-α alone and radiation, i.e., 6.5 days and 26.9 days, respectively(p<0.05). Enhancement factor was 1.29 in OCa-I, which showed supraadditive effect. TNF-α did not show significant delay of AGDs in the remaining 3 tumors compared to AGDs of TNF-α alone and radiation. Conclusions: TNF-α alone showed antitumor effects in MCa-K and OCa-I. In combination with radiation, TNF-α acted in supraadditive way in OCa-I only. The results of this study imply that the combination of TNF-α and radiation has different therapeutic potential depending on tumor model and further study is advocated. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean | - |
dc.publisher | 대한방사선종양학회 | - |
dc.relation.isPartOf | Journal of the Korean Society for Therapeutic Radiology and Oncology | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | 방사선의 항암작용에 대한 재조합 TNF-α의 효과 | - |
dc.title.alternative | Potentiation of Antitumor Effect of Radiotherapy by Recombinant Tumor Necrosis Factor-α | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiation Oncology (방사선종양학교실) | - |
dc.contributor.googleauthor | 성진실 | - |
dc.contributor.googleauthor | 신항철 | - |
dc.contributor.googleauthor | 김귀언 | - |
dc.contributor.googleauthor | 서창옥 | - |
dc.contributor.localId | A01956 | - |
dc.relation.journalcode | J01857 | - |
dc.contributor.alternativeName | Seong, Jin Sil | - |
dc.contributor.affiliatedAuthor | 성진실 | - |
dc.citation.volume | 16 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 225 | - |
dc.citation.endPage | 231 | - |
dc.identifier.bibliographicCitation | Journal of the Korean Society for Therapeutic Radiology and Oncology, Vol.16(3) : 225-231, 1998 | - |
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