95 267

Cited 0 times in

방사선의 항암작용에 대한 재조합 TNF-α의 효과

DC Field Value Language
dc.contributor.author성진실-
dc.date.accessioned2020-07-02T17:02:23Z-
dc.date.available2020-07-02T17:02:23Z-
dc.date.issued1998-
dc.identifier.issn1229-8719-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/176545-
dc.description.abstractPurpose : To determine whether TNF-α increases the antitumor effect of radiotherapy in murine syngeneic tumor system. Materials and Methods : Syngeneic murine tumors of MCa-K or MCa-4 (mammary carcinoma), OCa-I (ovarian carcinoma), or HCa-I(hepatocarcinoma were grown in hind legs of C3Hf/HeJ mice. When tumors were grown to 6 mm in mean diameter mice were treated with TNF-α, radiation, or combination of the both. Gamma-radiation was given as a single dose of 30 Gy for HCa-I and 15 Gy for other tumors using Cobalt-60 teletherapy unit. A novel TNF-α mutein developed in Korea, was intraperitoneally administered daily at a dose of 10 ug per mouse for 7 days. In combination of radiation and TNF-α, the drug was started 1 hour after radiation. Tumor growth delay assay was used to measure the tumor response to the treatment. Results : Among 4 tested tumors, TNF-α alone showed significant antitumor activity in MCa-K and OCa-I tumors, which showed absolute growth delay (AGD) of 5.0 days and 6.5 days, respectively. In combination with radiation, TNF-α showed significant delay of AGD (41.1 days) in OCA-I compared to AGDs of TNF-α alone and radiation, i.e., 6.5 days and 26.9 days, respectively(p<0.05). Enhancement factor was 1.29 in OCa-I, which showed supraadditive effect. TNF-α did not show significant delay of AGDs in the remaining 3 tumors compared to AGDs of TNF-α alone and radiation. Conclusions: TNF-α alone showed antitumor effects in MCa-K and OCa-I. In combination with radiation, TNF-α acted in supraadditive way in OCa-I only. The results of this study imply that the combination of TNF-α and radiation has different therapeutic potential depending on tumor model and further study is advocated.-
dc.description.statementOfResponsibilityopen-
dc.languageKorean-
dc.publisher대한방사선종양학회-
dc.relation.isPartOfJournal of the Korean Society for Therapeutic Radiology and Oncology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.title방사선의 항암작용에 대한 재조합 TNF-α의 효과-
dc.title.alternativePotentiation of Antitumor Effect of Radiotherapy by Recombinant Tumor Necrosis Factor-α-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiation Oncology (방사선종양학교실)-
dc.contributor.googleauthor성진실-
dc.contributor.googleauthor신항철-
dc.contributor.googleauthor김귀언-
dc.contributor.googleauthor서창옥-
dc.contributor.localIdA01956-
dc.relation.journalcodeJ01857-
dc.contributor.alternativeNameSeong, Jin Sil-
dc.contributor.affiliatedAuthor성진실-
dc.citation.volume16-
dc.citation.number3-
dc.citation.startPage225-
dc.citation.endPage231-
dc.identifier.bibliographicCitationJournal of the Korean Society for Therapeutic Radiology and Oncology, Vol.16(3) : 225-231, 1998-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.