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Seurm C-reactive protein: A predictor of mortality in CAPD patients

Authors
 Hyunjin Noh  ;  Seoung Woo Lee  ;  Shin Wook Kang  ;  Sug Kyun Shin  ;  Kyu Hun Choi  ;  Ho Yung Lee  ;  Dae Suk Han 
Citation
 PERITONEAL DIALYSIS INTERNATIONAL, Vol.18(4) : 387-394, 1998 
Journal Title
 PERITONEAL DIALYSIS INTERNATIONAL 
ISSN
 0896-8608 
Issue Date
1998
MeSH
Age Factors ; Biomarkers/blood ; C-Reactive Protein/analysis* ; Cholesterol/blood ; Cholesterol, HDL/blood ; Creatinine/blood ; Diabetes Complications ; Female ; Follow-Up Studies ; Forecasting ; Heart Diseases/complications ; Hematocrit ; Hospitalization ; Humans ; Length of Stay ; Male ; Middle Aged ; Nutrition Disorders/complications ; Peritoneal Dialysis, Continuous Ambulatory*/adverse effects ; Peritonitis/etiology ; Proportional Hazards Models ; Prospective Studies ; Serum Albumin/analysis ; Sex Factors ; Survival Analysis ; Survival Rate ; Urea/blood
Abstract
OBJECTIVE: To evaluate the predictive value of a single baseline serum C-reactive protein (sCRP) as a marker of mortality in continuous ambulatory peritoneal dialysis (CAPD) patients. DESIGN: A review of prospectively collected data in a 2-year follow-up study. SETTING: Tertiary medical center. PATIENTS: The study included 106 patients who were stable and had been on CAPD for a minimum of 3 months. MAIN OUTCOME MEASURES: Patient survival rate was the main outcome measure of this study. Other outcome measures were technique survival rate, peritonitis rate, and hospitalized days. Covariables used in the survival analysis were age, sex, the presence of cardiovascular disease or diabetes mellitus, sCRP, serum albumin, hematocrit, cholesterol, HDL-cholesterol, malnutrition by subjective global assessment (SGA), weekly Kt/V urea, and weekly standardized creatinine clearance (SCCr). RESULTS: The 2-year patient survival rate was significantly lower in the increased sCRP group than in the normal sCRP group (66.7% vs 94.1%, p = 0.001), although there was no significant difference in technique failure, peritonitis rate, and hospitalized days between the two groups. By Cox proportional hazards analysis, independent predictors of mortality were: cardiovascular disease (relative risk, RR = 8.96, p < 0.005); increased sCRP level (RR = 1.19, p < 0.05); and high hematocrit (RR = 1.18, p < 0.05). CONCLUSION: Serum CRP at enrollment is an independent predictor of 2-year patient survival in CAPD patients.
Full Text
http://www.pdiconnect.com/content/18/4/387.abstract?sid=71fec8fe-2426-46ae-aac1-df0238156fc2
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Shin Wook(강신욱) ORCID logo https://orcid.org/0000-0002-5677-4756
Choi, Kyu Hun(최규헌) ORCID logo https://orcid.org/0000-0003-0095-9011
Han, Dae Suk(한대석)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/176416
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