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Inhibitory effects of [6]-gingerol, a major pungent principle of ginger, on phorbol ester-induced inflammation, epidermal ornithine decarboxylase activity and skin tumor promotion in ICR mice

Authors
 Kwang-Kyun Park  ;  Kyung-Soo Chun  ;  Jong-Min Lee  ;  Sang Sup Lee  ;  Young-Joon Surh 
Citation
 CANCER LETTERS, Vol.129(2) : 139-144, 1998 
Journal Title
 CANCER LETTERS 
ISSN
 0304-3835 
Issue Date
1998
MeSH
9,10-Dimethyl-1,2-benzanthracene ; Animals ; Capillary Permeability/drug effects ; Catechols ; Curcumin/pharmacology ; Epidermis/drug effects ; Epidermis/enzymology* ; Fatty Alcohols/pharmacology* ; Female ; Inflammation/chemically induced ; Inflammation/prevention & control* ; Mice ; Mice, Inbred ICR ; Ornithine Decarboxylase/metabolism ; Ornithine Decarboxylase Inhibitors* ; Plants, Medicinal ; Skin Neoplasms/chemically induced ; Skin Neoplasms/prevention & control* ; Tetradecanoylphorbol Acetate
Abstract
A wide array of phytochemicals have been shown to possess potential cancer chemopreventive properties. Ginger contains pungent phenolic substances with pronounced antioxidative and antiinflammatory activities. In the present study, we have determined the antitumor promotional activity of [6]-gingerol, a major pungent principle of ginger, using a two-stage mouse skin carcinogenesis model. Topical application of [6]-gingerol onto shaven backs of female ICR mice prior to each topical dose of 12-O-tetradecanoylphorbol-13-acetate (TPA) significantly inhibited 7,12-dimethylbenz[a]anthracene-induced skin papillomagenesis. The compound also suppressed TPA-induced epidermal ornithine decarboxylase activity and inflammation.
Full Text
https://www.sciencedirect.com/science/article/pii/S0304383598000810
DOI
10.1016/s0304-3835(98)00081-0
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Park, Kwang Kyun(박광균)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/176375
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