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전신성 홍반성 루푸스 환자에서 임상적 질병 활성도와 혈청 인터루킨 8과의 연관성

Other Titles
 Correlation of serum Interleukin 8 with clinical disease activity in systemic lupus erythematosus (SLE) 
 이원기  ;  송창호  ;  박용범  ;  이충원  ;  서창희  ;  이찬희  ;  이지수  ;  김동수  ;  이수곤 
 Korean Journal of Medicine (대한내과학회지), Vol.54(6) : 770-777, 1998 
Journal Title
Korean Journal of Medicine(대한내과학회지)
Issue Date
Objectives : To evaluate seam Interleukin 8 (IL-8) as a predictor of disease activity in SLE and to provide insight into the potential role of IL-8 in the pathogenesis of SLE. Methods : Sixty-four paired sera from the 32 SLE patients and 10 healthy control sera were obtained. Serum IL-8 levels were determined by ELISA technique. Tests for other laboratory parameters, such as circulating immune complex (CIC), C3, C4, ANA, anti-dsDNA, Hb, Hct, leukocyte, lymphocyte, platelet and ESR were per(orbed for every sample coincidently with) assessment of clinical disease activity by the Lahita scales. Results ; We found that serum IL-8 levels in SLE patients were significantly higher than those of healthy controls. serum IL-8 levels significantly correlated with clinical disease activity. Serum IL-8 levels correlated with CIC, but it had no correlation with other laboratory parameters. Conclusion : These findings suggest that serum IL-8 can be used as a marker of disease activity in patients with SLE. These results may have implication in the pathogenesis of SLE.
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dong Soo(김동수)
Park, Yong Beom(박용범)
Lee, Soo Kon(이수곤)
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