전신성 홍반성 루푸스 환자에서 임상적 질병 활성도와 혈청 인터루킨 8과의 연관성

Abstract

Objectives : To evaluate seam Interleukin 8 (IL-8) as a predictor of disease activity in SLE and to provide insight into the potential role of IL-8 in the pathogenesis of SLE. Methods : Sixty-four paired sera from the 32 SLE patients and 10 healthy control sera were obtained. Serum IL-8 levels were determined by ELISA technique. Tests for other laboratory parameters, such as circulating immune complex (CIC), C3, C4, ANA, anti-dsDNA, Hb, Hct, leukocyte, lymphocyte, platelet and ESR were per(orbed for every sample coincidently with) assessment of clinical disease activity by the Lahita scales. Results ; We found that serum IL-8 levels in SLE patients were significantly higher than those of healthy controls. serum IL-8 levels significantly correlated with clinical disease activity. Serum IL-8 levels correlated with CIC, but it had no correlation with other laboratory parameters. Conclusion : These findings suggest that serum IL-8 can be used as a marker of disease activity in patients with SLE. These results may have implication in the pathogenesis of SLE.