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Effect of nitric oxide on hydrogen peroxide-induced damage in isolated rabbit gastric glands

Authors
 Hyeyoung Kim  ;  Kyung Hwan Kim 
Citation
 PHARMACOLOGY, Vol.57(6) : 323-330, 1998 
Journal Title
 PHARMACOLOGY 
ISSN
 0031-7012 
Issue Date
1998
MeSH
Animals ; Drug Interactions ; Enzyme Inhibitors/pharmacology ; Gastric Mucosa/drug effects* ; Gastric Mucosa/enzymology ; Gastric Mucosa/metabolism ; Glutathione Peroxidase/metabolism ; Hydrogen Peroxide/toxicity* ; Lipid Peroxides/biosynthesis* ; NG-Nitroarginine Methyl Ester/pharmacology ; Nitric Oxide/pharmacology* ; Nitroprusside/pharmacology ; Peroxidases/pharmacology ; Rabbits
Abstract
The present study aims at investigating the effects of nitric oxide (NO) on hydrogen peroxide (H2O2)-induced damage in isolated rabbit gastric glands. NO synthesis modulators such as L-arginine and NG-nitro-L-arginine methyl ester (L-NAME) and an NO donor, sodium nitroprusside, were added to isolated rabbit gastric glands exposed to H2O2, generated by glucose oxidase acting on beta-D-glucose. As a result, glucose/glucose oxidase caused an increase in lipid peroxide production and decreases in reduced glutathione (GSH) content, GSH peroxidase activity, nitrite release, and mucus secretion in gastric glands. The alterations in lipid peroxide production, GSH content, and mucus secretion were prevented by pretreatment with L-arginine, a substrate for NO synthase and sodium nitroprusside, but not by L-NAME. In conclusion, NO protects gastric glands from H2O2 by inhibiting lipid peroxidation and maintaining cellular GSH content and mucus secretion.
Full Text
http://www.karger.com/Article/FullText/28258
DOI
10.1159/000028258
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Hwan(김경환)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/176308
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