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Comparison of High-Throughput Fully Automated Immunoanalyzers for Detecting Hepatitis B Virus Infection
DC Field | Value | Language |
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dc.contributor.author | 김현숙 | - |
dc.contributor.author | 박윤희 | - |
dc.contributor.author | 원동주 | - |
dc.date.accessioned | 2020-06-17T01:04:40Z | - |
dc.date.available | 2020-06-17T01:04:40Z | - |
dc.date.issued | 2020-05 | - |
dc.identifier.issn | 0003-9985 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/176238 | - |
dc.description.abstract | Context.—: High-throughput automated immunoanalyzers for hepatitis B virus serologic markers have been introduced but have not been compared to existing systems. Objective.—: To compare hepatitis B surface antigen, hepatitis B surface antibody, and total hepatitis B core antibody analyses between our Architect i2000 platform and newer high-throughput fully automated immunoanalyzers. Design.—: From May to June 2018, a total of 932, 914, and 1055 samples tested for hepatitis B surface antigen, hepatitis B surface antibody, and total hepatitis B core antibody, respectively, with the Architect i2000 system for routine testing in our center were tested again with Alinity i, Atellica IM, and Cobas e801 systems. Results.—: Total concordance rates among the systems were 98.0%, 89.5%, and 93.0% for hepatitis B surface antigen, hepatitis B surface antibody, and total hepatitis B core antibody, respectively. Cohen's κ values exceeded 0.8. The correlations between serum hepatitis B surface antibody levels quantified by all 4 systems were high (r > 0.85). The hepatitis B surface antibody averages were greater for the Alinity i, Atellica IM, and Cobas e801 than for the Architect i2000 (P < .001). Conclusions.—: Alinity i, Atellica IM, and Cobas e801 automated immunoanalyzers performed well when compared with the existing Architect i2000 system with regard to detection of hepatitis B viral infection. However, the new systems have higher titer and positivity rates for hepatitis B surface antibody and are more sensitive. Notably, the Atellica IM has a lower positive rate for total hepatitis B core antibody than does the Architect i2000. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | College of American Pathologists | - |
dc.relation.isPartOf | ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Comparison of High-Throughput Fully Automated Immunoanalyzers for Detecting Hepatitis B Virus Infection | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학교실) | - |
dc.contributor.googleauthor | Dongju Won | - |
dc.contributor.googleauthor | Younhee Park | - |
dc.contributor.googleauthor | Dasom Choi | - |
dc.contributor.googleauthor | Hyon-Suk Kim | - |
dc.identifier.doi | 10.5858/arpa.2019-0096-OA | - |
dc.contributor.localId | A01117 | - |
dc.contributor.localId | A01606 | - |
dc.contributor.localId | A05763 | - |
dc.relation.journalcode | J00228 | - |
dc.identifier.eissn | 1543-2165 | - |
dc.identifier.pmid | 31596621 | - |
dc.contributor.alternativeName | Kim, Hyon Suk | - |
dc.contributor.affiliatedAuthor | 김현숙 | - |
dc.contributor.affiliatedAuthor | 박윤희 | - |
dc.contributor.affiliatedAuthor | 원동주 | - |
dc.citation.volume | 144 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 612 | - |
dc.citation.endPage | 619 | - |
dc.identifier.bibliographicCitation | ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE, Vol.144(5) : 612-619, 2020-05 | - |
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