Cited 9 times in
Hepatic Fibrosis Assessed Using Fibrosis-4 Index Is Predictive of All-Cause Mortality in Patients With Chronic Obstructive Pulmonary Disease
DC Field | Value | Language |
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dc.contributor.author | 김승업 | - |
dc.contributor.author | 김영삼 | - |
dc.contributor.author | 박무석 | - |
dc.contributor.author | 임아영 | - |
dc.contributor.author | 장준 | - |
dc.contributor.author | 정지예 | - |
dc.date.accessioned | 2020-06-17T00:57:32Z | - |
dc.date.available | 2020-06-17T00:57:32Z | - |
dc.date.issued | 2020-04 | - |
dc.identifier.issn | 1176-9106 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/176197 | - |
dc.description.abstract | Background: Various comorbidities influence the prognosis of patients with chronic obstructive pulmonary disease (COPD). We investigated if liver fibrosis assessed using fibrosis-4 index (FIB-4) is associated with all-cause mortality in patients with COPD. Methods: We included 756 patients diagnosed with COPD between 2006 and 2010. Medical records were retrospectively reviewed until 2018. FIB-4 was calculated using the following equation: [age (years) × aspartate aminotransferase (IU/L)/(platelet count (109/L) × √alanine aminotransferase (IU/L))]. Results: From a total of 756 patients, 582 (76.9%) patients were categorized into survivor and 174 (23.1%) into non-survivor groups. The non-survivor group was significantly older with a higher proportion of male, smoker and lower FEV1/FVC ratio than the survivor group (all P<0.05). Various comorbidities were more frequently observed in the non-survivor group (P<0.05). In addition, the non-survivor group had significantly higher FIB-4 than the survivor group (1.8 vs 1.4, P<0.001). In multivariate analysis, older age (hazard ratio [HR]=1.05), underlying malignancy (HR=2.94), coronary artery occlusive disease (HR=1.58), higher FIB-4 (HR=1.15), and higher GOLD stage (HR=1.26) were significantly associated with the increased risk of all-cause mortality (P<0.05), whereas body mass index (HR=0.95) was independently protective for all-cause mortality (all P<0.05). The high FIB-4 (>1.57) group showed a significantly lower cumulative survival rate than the low FIB-4 (≤1.05) group (P=0.031, Log-rank test). In multivariate regression analysis, higher FIB-4 independently predicted the risk of acute exacerbation (odds ratio=1.08, P=0.034). Conclusion: Higher fibrotic burden assessed using FIB-4 was independently predictive of the increased risk of all-cause mortality and acute exacerbation in patients with COPD. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | DOVE Medical Press | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Hepatic Fibrosis Assessed Using Fibrosis-4 Index Is Predictive of All-Cause Mortality in Patients With Chronic Obstructive Pulmonary Disease | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Seung Hyun Yong | - |
dc.contributor.googleauthor | Ah Young Leem | - |
dc.contributor.googleauthor | Young Sam Kim | - |
dc.contributor.googleauthor | Moo Suk Park | - |
dc.contributor.googleauthor | Joon Chang | - |
dc.contributor.googleauthor | Seung Up Kim | - |
dc.contributor.googleauthor | Ji Ye Jung | - |
dc.identifier.doi | 10.2147/COPD.S242863 | - |
dc.contributor.localId | A00654 | - |
dc.contributor.localId | A00707 | - |
dc.contributor.localId | A01457 | - |
dc.contributor.localId | A03382 | - |
dc.contributor.localId | A03472 | - |
dc.contributor.localId | A03735 | - |
dc.relation.journalcode | J01095 | - |
dc.identifier.eissn | 1178-2005 | - |
dc.identifier.pmid | 32368029 | - |
dc.subject.keyword | FIB-4 | - |
dc.subject.keyword | chronic obstructive pulmonary disease | - |
dc.subject.keyword | exacerbation | - |
dc.subject.keyword | liver fibrosis | - |
dc.subject.keyword | mortality | - |
dc.contributor.alternativeName | Kim, Seung Up | - |
dc.contributor.affiliatedAuthor | 김승업 | - |
dc.contributor.affiliatedAuthor | 김영삼 | - |
dc.contributor.affiliatedAuthor | 박무석 | - |
dc.contributor.affiliatedAuthor | 임아영 | - |
dc.contributor.affiliatedAuthor | 장준 | - |
dc.contributor.affiliatedAuthor | 정지예 | - |
dc.citation.volume | 15 | - |
dc.citation.startPage | 831 | - |
dc.citation.endPage | 839 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, Vol.15 : 831-839, 2020-04 | - |
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