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Stroke and Systemic Embolism and Other Adverse Outcomes of Heart Failure With Preserved and Reduced Ejection Fraction in Patients With Atrial Fibrillation (From the COmparison Study of Drugs for Symptom Control and Complication prEvention of Atrial Fibrillation [CODE-AF])

DC Field Value Language
dc.contributor.author김창수-
dc.contributor.author김태훈-
dc.contributor.author엄재선-
dc.contributor.author정보영-
dc.date.accessioned2020-06-17T00:57:06Z-
dc.date.available2020-06-17T00:57:06Z-
dc.date.issued2020-01-
dc.identifier.issn0002-9149-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/176194-
dc.description.abstractIt is unknown whether heart failure (HF) with preserved ejection fraction (HFpEF) and HF with reduced ejection fraction (HFrEF) carry a similar risk of stroke or systemic embolism (SE) and other outcomes in patients with nonvalvular atrial fibrillation (AF). A prospective, multicenter outpatient registry with echocardiographic data which enrolled 10,589 patients from June 2016 to May 2019 was analyzed. In this registry, 935 (8.8%) patients had HF, and the proportions of patients with HFpEF and HFrEF were 43.2% and 56.8%, respectively. During follow-up over 1.33 years, 11 (2.07 per 100 person-years [PYR]) and 5 (0.76 per 100 PYR) patients had stroke/SE in the HFpEF and HFrEF groups, respectively, whereas 102 patients (0.84 per 100 PYR) had these sequelae in the no-HF group. The HFpEF group had a significantly higher cumulative incidence of stroke/SE (p = 0.004) and risk of stroke/SE (adjusted hazard ratio [HR] 2.23, 95% confidence interval [CI] 1.19 to 4.18) than the no-HF group. The risk of stroke/SE in the HFpEF group compared with that in the no-HF group was consistently increased even in patients on oral anticoagulation therapy (adjusted HR 2.55, 95% CI 1.31 to 4.96). There was a correlation between larger left atrial size and risk of stroke/SE (adjusted HR 1.53, 95% CI 1.03 to 2.29), but not between reduced left ventricular ejection fraction and this risk. In conclusion, these results suggest that strict oral anticoagulation therapy helps reduce the risk of stroke/SE in patients with nonvalvular AF and HFpEF, especially in those with a larger left atrial size.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherExcerpta Medica-
dc.relation.isPartOfAMERICAN JOURNAL OF CARDIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAdministration, Oral-
dc.subject.MESHAged-
dc.subject.MESHAnticoagulants / administration & dosage*-
dc.subject.MESHAtrial Fibrillation / complications*-
dc.subject.MESHAtrial Fibrillation / diagnosis-
dc.subject.MESHAtrial Fibrillation / drug therapy-
dc.subject.MESHEchocardiography-
dc.subject.MESHEmbolism / epidemiology-
dc.subject.MESHEmbolism / etiology*-
dc.subject.MESHEmbolism / prevention & control-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHHeart Failure / complications*-
dc.subject.MESHHeart Failure / drug therapy-
dc.subject.MESHHeart Failure / physiopathology-
dc.subject.MESHHeart Ventricles / diagnostic imaging-
dc.subject.MESHHeart Ventricles / physiopathology-
dc.subject.MESHHumans-
dc.subject.MESHIncidence-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPrognosis-
dc.subject.MESHProspective Studies-
dc.subject.MESHRepublic of Korea / epidemiology-
dc.subject.MESHRisk Assessment / methods*-
dc.subject.MESHRisk Factors-
dc.subject.MESHStroke / epidemiology-
dc.subject.MESHStroke / etiology*-
dc.subject.MESHStroke / prevention & control-
dc.subject.MESHStroke Volume / physiology*-
dc.subject.MESHSurvival Rate / trends-
dc.subject.MESHVentricular Function, Left / physiology-
dc.titleStroke and Systemic Embolism and Other Adverse Outcomes of Heart Failure With Preserved and Reduced Ejection Fraction in Patients With Atrial Fibrillation (From the COmparison Study of Drugs for Symptom Control and Complication prEvention of Atrial Fibrillation [CODE-AF])-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Preventive Medicine and Public Health (예방의학교실)-
dc.contributor.googleauthorSeyong Chung-
dc.contributor.googleauthorTae-Hoon Kim-
dc.contributor.googleauthorJae-Sun Uhm-
dc.contributor.googleauthorMyung-Jin Cha-
dc.contributor.googleauthorJung-Myung Lee-
dc.contributor.googleauthorJunbeom Park-
dc.contributor.googleauthorJin-Kyu Park-
dc.contributor.googleauthorKi-Woon Kang-
dc.contributor.googleauthorJun Kim-
dc.contributor.googleauthorHyung Wook Park-
dc.contributor.googleauthorEue-Keun Choi-
dc.contributor.googleauthorJin-Bae Kim-
dc.contributor.googleauthorChang-Soo Kim-
dc.contributor.googleauthorYoung Soo Lee-
dc.contributor.googleauthorJaemin Shim-
dc.contributor.googleauthorBoyoung Joung-
dc.identifier.doi10.1016/j.amjcard.2019.09.035-
dc.contributor.localIdA01042-
dc.contributor.localIdA01085-
dc.contributor.localIdA02337-
dc.contributor.localIdA03609-
dc.relation.journalcodeJ00071-
dc.identifier.eissn1879-1913-
dc.identifier.pmid31699363-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S000291491931104X-
dc.contributor.alternativeNameKim, Chang Soo-
dc.contributor.affiliatedAuthor김창수-
dc.contributor.affiliatedAuthor김태훈-
dc.contributor.affiliatedAuthor엄재선-
dc.contributor.affiliatedAuthor정보영-
dc.citation.volume125-
dc.citation.number1-
dc.citation.startPage68-
dc.citation.endPage75-
dc.identifier.bibliographicCitationAMERICAN JOURNAL OF CARDIOLOGY, Vol.125(1) : 68-75, 2020-01-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers

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