Cited 9 times in
Efficacy and Safety of Omega-3 Fatty Acids in Patients Treated With Statins for Residual Hypertriglyceridemia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
DC Field | Value | Language |
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dc.contributor.author | 이용호 | - |
dc.date.accessioned | 2020-06-17T00:56:22Z | - |
dc.date.available | 2020-06-17T00:56:22Z | - |
dc.date.issued | 2020-02 | - |
dc.identifier.issn | 2233-6079 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/176190 | - |
dc.description.abstract | Background: Cardiovascular risk remains increased despite optimal low density lipoprotein cholesterol (LDL-C) level induced by intensive statin therapy. Therefore, recent guidelines recommend non-high density lipoprotein cholesterol (non-HDL-C) as a secondary target for preventing cardiovascular events. The aim of this study was to assess the efficacy and tolerability of omega-3 fatty acids (OM3-FAs) in combination with atorvastatin compared to atorvastatin alone in patients with mixed dyslipidemia. Methods: This randomized, double-blind, placebo-controlled, parallel-group, and phase III multicenter study included adults with fasting triglyceride (TG) levels ≥200 and <500 mg/dL and LDL-C levels <110 mg/dL. Eligible subjects were randomized to ATOMEGA (OM3-FAs 4,000 mg plus atorvastatin calcium 20 mg) or atorvastatin 20 mg plus placebo groups. The primary efficacy endpoints were the percent changes in TG and non-HDL-C levels from baseline at the end of treatment. Results: After 8 weeks of treatment, the percent changes from baseline in TG (-29.8% vs. 3.6%, P<0.001) and non-HDL-C (-10.1% vs. 4.9%, P<0.001) levels were significantly greater in the ATOMEGA group (n=97) than in the atorvastatin group (n=103). Moreover, the proportion of total subjects reaching TG target of <200 mg/dL in the ATOMEGA group was significantly higher than that in the atorvastatin group (62.9% vs. 22.3%, P<0.001). The incidence of adverse events did not differ between the two groups. Conclusion: The addition of OM3-FAs to atorvastatin improved TG and non-HDL-C levels to a significant extent compared to atorvastatin alone in subjects with residual hypertriglyceridemia. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Korean Diabetes Association | - |
dc.relation.isPartOf | DIABETES & METABOLISM JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Efficacy and Safety of Omega-3 Fatty Acids in Patients Treated With Statins for Residual Hypertriglyceridemia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Ji Eun Jun | - |
dc.contributor.googleauthor | In Kyung Jeong | - |
dc.contributor.googleauthor | Jae Myung Yu | - |
dc.contributor.googleauthor | Sung Rae Kim | - |
dc.contributor.googleauthor | In Kye Lee | - |
dc.contributor.googleauthor | Kyung Ah Han | - |
dc.contributor.googleauthor | Sung Hee Choi | - |
dc.contributor.googleauthor | Soo Kyung Kim | - |
dc.contributor.googleauthor | Hyeong Kyu Park | - |
dc.contributor.googleauthor | Ji Oh Mok | - |
dc.contributor.googleauthor | Yong Ho Lee | - |
dc.contributor.googleauthor | Hyuk Sang Kwon | - |
dc.contributor.googleauthor | So Hun Kim | - |
dc.contributor.googleauthor | Ho Cheol Kang | - |
dc.contributor.googleauthor | Sang Ah Lee | - |
dc.contributor.googleauthor | Chang Beom Lee | - |
dc.contributor.googleauthor | Kyung Mook Choi | - |
dc.contributor.googleauthor | Sung Ho Her | - |
dc.contributor.googleauthor | Won Yong Shin | - |
dc.contributor.googleauthor | Mi Seung Shin | - |
dc.contributor.googleauthor | Hyo Suk Ahn | - |
dc.contributor.googleauthor | Seung Ho Kang | - |
dc.contributor.googleauthor | Jin Man Cho | - |
dc.contributor.googleauthor | Sang Ho Jo | - |
dc.contributor.googleauthor | Tae Joon Cha | - |
dc.contributor.googleauthor | Seok Yeon Kim | - |
dc.contributor.googleauthor | Kyung Heon Won | - |
dc.contributor.googleauthor | Dong Bin Kim | - |
dc.contributor.googleauthor | Jae Hyuk Lee | - |
dc.contributor.googleauthor | Moon Kyu Lee | - |
dc.identifier.doi | 10.4093/dmj.2018.0265 | - |
dc.contributor.localId | A02989 | - |
dc.relation.journalcode | J00720 | - |
dc.identifier.eissn | 2233-6087 | - |
dc.identifier.pmid | 31237134 | - |
dc.subject.keyword | Atorvastatin | - |
dc.subject.keyword | Fatty acids, omega-3 | - |
dc.subject.keyword | Hypertriglyceridemia | - |
dc.contributor.alternativeName | Lee, Yong Ho | - |
dc.contributor.affiliatedAuthor | 이용호 | - |
dc.citation.volume | 44 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 78 | - |
dc.citation.endPage | 90 | - |
dc.identifier.bibliographicCitation | DIABETES & METABOLISM JOURNAL, Vol.44(1) : 78-90, 2020-02 | - |
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