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High Triglyceride to HDL Cholesterol Ratio Is Associated With Low Testosterone and Sex Hormone-Binding Globulin Levels in Middle-aged and Elderly Men

Authors
 Tae-Ha Chung  ;  Yu-Jin Kwon  ;  Yong-Jae Lee 
Citation
 AGING MALE, Vol.23(2) : 93-97, 2020-06 
Journal Title
 AGING MALE 
ISSN
 1368-5538 
Issue Date
2020-06
Keywords
TG/HDL ratio ; inflammation ; insulin resistance ; sex hormone-binding protein ; testosterone
Abstract
Objective: We investigated the association between the triglycerides to high-density lipoprotein cholesterol (TG/HDL) ratio and low testosterone and sex hormone-binding globulin (SHBG) levels in middle-aged and elderly men.Methods: This cross-sectional study included 1055 men aged ≥45 years who underwent a medical examination. The cutoff points for low testosterone and SHBG levels were determined as 12.2 and 29.4 nmol/L, which corresponded to the 25th percentile of the current sample. The odds ratios (ORs) and 95% confidence intervals (95% CIs) for low testosterone and SHBG levels were calculated after adjusting for confounding variables across TG/HDL ratio quartiles (Q1: ≤ 1.70, Q2: 1.71-2.54, Q3: 2.55-3.77, Q4: ≥3.78) using multiple logistic regression analysis.Results: The proportion of subjects with low testosterone and SHBG levels significantly increased in accordance with TG/HDL ratio quartile. The ORs (95% CIs) of the lowest TG/HDL ratio quartile compared to the highest TG/HDL ratio quartile for low levels of testosterone and SHBG were 1.96 (1.13-2.75) and 3.90 (2.38-6.38), respectively, after adjusting for age, body mass index, smoking status, alcohol drinking, regular exercise, diastolic blood pressure, fasting plasma glucose, and total cholesterol level.Conclusions: The TG/HDL ratio was inversely associated with testosterone and SHBG levels in middle-aged and elderly Korean men.
Full Text
https://www.tandfonline.com/doi/full/10.1080/13685538.2018.1501015
DOI
10.1080/13685538.2018.1501015
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Yu-Jin(권유진) ORCID logo https://orcid.org/0000-0002-9021-3856
Lee, Yong Jae(이용제) ORCID logo https://orcid.org/0000-0002-6697-476X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/176111
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