Cited 9 times in
Protective Role of Cardiac-Specific Overexpression of caveolin-3 in Cirrhotic Cardiomyopathy
DC Field | Value | Language |
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dc.contributor.author | 김소연 | - |
dc.date.accessioned | 2020-06-17T00:32:57Z | - |
dc.date.available | 2020-06-17T00:32:57Z | - |
dc.date.issued | 2020-03 | - |
dc.identifier.issn | 0193-1857 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/176018 | - |
dc.description.abstract | Cirrhotic cardiomyopathy is a clinical syndrome in patients with liver cirrhosis characterized by blunted cardiac contractile responses to stress and/or heart rate-corrected QT (QTc) interval prolongation. Caveolin-3 (Cav-3) plays a critical role in cardiac protection and is an emerging therapeutic target for heart disease. We investigated the protective role of cardiac-specific overexpression (OE) of Cav-3 in cirrhotic cardiomyopathy. Biliary fibrosis was induced in male Cav-3 OE mice and transgene negative (TGneg) littermates by feeding a diet containing 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC; 0.1%) for 3 wk. Liver pathology and blood chemistries were assessed, and stress echocardiography, telemetry, and isolated heart perfusion studies to assess adrenergic responsiveness were performed. Cav-3 OE mice showed a similar degree of hyperdynamic contractility, pulmonary hypertension, and QTc interval prolongation as TGneg mice after 3 wk of DDC diet. Blunted systolic responses were shown in both DDC-fed Cav-3 OE and TGneg hearts after in vivo isoproterenol challenge. However, QTc interval prolongation after in vivo isoproterenol challenge was significantly less in DDC-fed Cav-3 OE hearts compared with DDC-fed TGneg hearts. In ex vivo perfused hearts, where circulatory factors are absent, isoproterenol challenge showed hearts from DDC-fed Cav-3 OE mice had better cardiac contractility and relaxation compared with DDC-fed TGneg hearts. Although Cav-3 OE in the heart did not prevent cardiac alterations in DDC-induced biliary fibrosis, cardiac expression of Cav-3 reduced QTc interval prolongation after adrenergic stimulation in cirrhosis.NEW & NOTEWORTHY Prevalence of cirrhotic cardiomyopathy is up to 50% in cirrhotic patients, and liver transplantation is the only treatment. However, cirrhotic cardiomyopathy is associated with perioperative morbidity and mortality after liver transplantation; therefore, management of cirrhotic cardiomyopathy is crucial for successful liver transplantation. This study shows cardiac myocyte specific overexpression of caveolin-3 (Cav-3) provides better cardiac contractile responses and less corrected QT prolongation during adrenergic stress in a cirrhotic cardiomyopathy model, suggesting beneficial effects of Cav-3 expression in cirrhotic cardiomyopathy. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | American Physiological Society | - |
dc.relation.isPartOf | AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Protective Role of Cardiac-Specific Overexpression of caveolin-3 in Cirrhotic Cardiomyopathy | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) | - |
dc.contributor.googleauthor | So Yeon Kim | - |
dc.contributor.googleauthor | Kang Ho Kim | - |
dc.contributor.googleauthor | Jan M Schilling | - |
dc.contributor.googleauthor | Joseph Leem | - |
dc.contributor.googleauthor | Mehul Dhanani | - |
dc.contributor.googleauthor | Brian P Head | - |
dc.contributor.googleauthor | David M Roth | - |
dc.contributor.googleauthor | Alice E Zemljic-Harpf | - |
dc.contributor.googleauthor | Hemal H Patel | - |
dc.identifier.doi | 10.1152/ajpgi.00346.2019 | - |
dc.contributor.localId | A00616 | - |
dc.relation.journalcode | J00104 | - |
dc.identifier.eissn | 1522-1547 | - |
dc.identifier.pmid | 31961720 | - |
dc.identifier.url | https://journals.physiology.org/doi/full/10.1152/ajpgi.00346.2019 | - |
dc.subject.keyword | adrenergic | - |
dc.subject.keyword | caveolin | - |
dc.subject.keyword | cirrhotic cardiomyopathy | - |
dc.contributor.alternativeName | Kim, So Yeon | - |
dc.contributor.affiliatedAuthor | 김소연 | - |
dc.citation.volume | 318 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | G531 | - |
dc.citation.endPage | G541 | - |
dc.identifier.bibliographicCitation | AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, Vol.318(3) : G531-G541, 2020-03 | - |
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