Cited 16 times in
Design and Validation of Risk Prediction Model for Hepatocellular Carcinoma Development After Sustained Virological Response in Patients With Chronic Hepatitis C
DC Field | Value | Language |
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dc.contributor.author | 김도영 | - |
dc.contributor.author | 김범경 | - |
dc.contributor.author | 김승업 | - |
dc.contributor.author | 박준용 | - |
dc.contributor.author | 안상훈 | - |
dc.contributor.author | 전호수 | - |
dc.contributor.author | 한광협 | - |
dc.date.accessioned | 2020-06-17T00:28:54Z | - |
dc.date.available | 2020-06-17T00:28:54Z | - |
dc.date.issued | 2020-03 | - |
dc.identifier.issn | 0954-691X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/175989 | - |
dc.description.abstract | Objectives: Hepatocellular carcinoma can develop after hepatitis C virus eradication. We developed a new hepatocellular carcinoma risk score (HCC-SVR score) based on independent predictors for chronic hepatitis C after sustained virological response. Methods: Between 2003 and 2016, a total of 1193 patients with chronic hepatitis C who achieved sustained virological response through antiviral therapy were included (669 for training cohort and 524 for validation cohort). The HCC-SVR score was developed using multivariate Cox proportional hazards regression modelling. Results: Hepatocellular carcinoma (n = 19) occurred more frequently in older, male patients and was associated with liver cirrhosis; hypertension; diabetes; lower platelet count; higher alpha-fetoprotein, aspartate, and alanine aminotransferase; lower total cholesterol; and higher fibrosis-4 index (FIB-4) (all P < 0.05). FIB-4 (hazard ratio = 1.080), male gender (hazard ratio = 8.189), and higher alpha-fetoprotein (hazard ratio = 1.060) independently predicted hepatocellular carcinoma (all P < 0.05). HCC-SVR score successfully predicted hepatocellular carcinoma development risk [area under receiver operating characteristic curve (AUC) = 0.771, 0.857, and 0.911 at 2, 4, and 6 years, respectively]. The cumulative incidence rate of hepatocellular carcinoma differed significantly among groups stratified by HCC-SVR risk score (0-2 points, low; 3-7 points, intermediate; 8-9 points, high risk) (all P < 0.05 by log-rank test). HCC-SVR score was maintained in a validation cohort (n = 524) (AUC = 0.728 at 2 years, 0.737 at 4 years, and 0.809 at 6 years). Conclusion: The HCC-SVR score enables risk stratification for hepatocellular carcinoma development at sustained virological response in patients with chronic hepatitis C. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Lippincott Williams And Wilkins | - |
dc.relation.isPartOf | EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Design and Validation of Risk Prediction Model for Hepatocellular Carcinoma Development After Sustained Virological Response in Patients With Chronic Hepatitis C | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Ho Soo Chun | - |
dc.contributor.googleauthor | Beom Kyung Kim | - |
dc.contributor.googleauthor | Jun Yong Park | - |
dc.contributor.googleauthor | Do Young Kim | - |
dc.contributor.googleauthor | Sang Hoon Ahn | - |
dc.contributor.googleauthor | Kwang-Hyub Han | - |
dc.contributor.googleauthor | Cheol-Hyung Lee | - |
dc.contributor.googleauthor | Yun Bin Lee | - |
dc.contributor.googleauthor | Eun Ju Cho | - |
dc.contributor.googleauthor | Su Jong Yu | - |
dc.contributor.googleauthor | Yoon Jun Kim | - |
dc.contributor.googleauthor | Jung-Hwan Yoon | - |
dc.contributor.googleauthor | Jeong-Hoon Lee | - |
dc.contributor.googleauthor | Seung Up Kim | - |
dc.identifier.doi | 10.1097/MEG.0000000000001512 | - |
dc.contributor.localId | A00385 | - |
dc.contributor.localId | A00487 | - |
dc.contributor.localId | A00654 | - |
dc.contributor.localId | A01675 | - |
dc.contributor.localId | A02226 | - |
dc.contributor.localId | A05908 | - |
dc.contributor.localId | A04268 | - |
dc.relation.journalcode | J00821 | - |
dc.identifier.eissn | 1473-5687 | - |
dc.identifier.pmid | 32011388 | - |
dc.identifier.url | https://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00042737-202003000-00013&LSLINK=80&D=ovft | - |
dc.contributor.alternativeName | Kim, Do Young | - |
dc.contributor.affiliatedAuthor | 김도영 | - |
dc.contributor.affiliatedAuthor | 김범경 | - |
dc.contributor.affiliatedAuthor | 김승업 | - |
dc.contributor.affiliatedAuthor | 박준용 | - |
dc.contributor.affiliatedAuthor | 안상훈 | - |
dc.contributor.affiliatedAuthor | 전호수 | - |
dc.contributor.affiliatedAuthor | 한광협 | - |
dc.citation.volume | 32 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 378 | - |
dc.citation.endPage | 385 | - |
dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, Vol.32(3) : 378-385, 2020-03 | - |
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