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Association of Resting Heart Rate With Nonalcoholic Fatty Liver Disease in Postmenopausal Women

Authors
 Hong-Bae Kim  ;  Yong-Jae Lee 
Citation
 MEDICINE, Vol.99(14) : e19529, 2020-04 
Journal Title
MEDICINE
ISSN
 0025-7974 
Issue Date
2020-04
MeSH
Age Factors ; Aged ; Blood Glucose ; Blood Pressure ; Body Mass Index ; Cigarette Smoking / epidemiology ; Cross-Sectional Studies ; Female ; Heart Rate / physiology* ; Humans ; Lipids / blood ; Liver Function Tests ; Middle Aged ; Non-alcoholic Fatty Liver Disease / epidemiology* ; Non-alcoholic Fatty Liver Disease / physiopathology* ; Postmenopause / physiology*
Abstract
Resting heart rate, a simple and useful indicator of autonomic function, and its imbalance has emerged as an independent predictor of cardio metabolic diseases. Nonalcoholic fatty liver disease (NAFLD) is increasingly being diagnosed worldwide and is strongly associated with the features of cardiometabolic diseases. This study aimed to examine the association between resting heart rate and NAFLD in postmenopausal women.The cross-sectional study included 1017 postmenopausal women aged ≥46 years, who attended a health examination program. Resting heart rate and NAFLD were measured in all subjects who underwent a medical examination. Resting heart rate quartiles were categorized as follows: Q1: 56 to 65, Q2: 66 to 71, Q3: 72 to 78, and Q4: 79 to 99 beats/min. The odds ratios and 95% confidence intervals for NAFLD were calculated after adjusting for confounding variables across resting heart rate quartiles using multiple logistic regression analysis.The prevalence of NAFLD increased with increasing resting heart rate quartiles: 28.2% for Q1, 31.5% for Q2, 33.4% for Q3, and 38.1% for Q4 (P < .001). Compared to the 1st quartile, the odds ratio (95% confidence intervals) of NAFLD in the 4th quartile of resting heart rates was 2.11 (1.17-3.42) after adjusting for age, body mass index, cigarette smoking, regular exercise, blood pressure, total cholesterol, triglyceride, aspartate aminotransferase, and alanine aminotransferase levels.Resting heart rate was positively associated with NAFLD in postmenopausal women, suggesting that it could be a useful additional measure to assess the risk for NAFLD in postmenopausal women.
Files in This Item:
T202001047.pdf Download
DOI
10.1097/MD.0000000000019529
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
Yonsei Authors
Lee, Yong Jae(이용제) ORCID logo https://orcid.org/0000-0002-6697-476X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/175979
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