Cited 7 times in
Plasma Fibroblast Growth Factor 23 Concentration Is Associated With Intracranial Cerebral Atherosclerosis in Acute Ischemic Stroke Patients
DC Field | Value | Language |
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dc.contributor.author | 김진권 | - |
dc.date.accessioned | 2020-06-17T00:24:55Z | - |
dc.date.available | 2020-06-17T00:24:55Z | - |
dc.date.issued | 2020-01 | - |
dc.identifier.issn | 1738-6586 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/175954 | - |
dc.description.abstract | Background and purpose: Fibroblast growth factor 23 (FGF23) is associated with atherosclerosis via nitric-oxide-associated endothelial dysfunction and calcium-phosphate-related bone mineralization. This study aimed to determine the association of the plasma FGF23 concentration with intracranial cerebral atherosclerosis (ICAS) and extracranial cerebral atherosclerosis (ECAS). Methods: We prospectively enrolled 262 first-ever ischemic stroke patients in whom brain magnetic resonance was performed and a blood sample acquired within 24 h after admission. Plasma FGF23 concentrations were measured using an enzyme-linked immunosorbent assay. The presence of ICAS or ECAS was defined as a ≥50% decrease in arterial diameter in magnetic resonance angiography. The burden of cerebral atherosclerosis was calculated by adding the total number of vessels defined as ICAS or ECAS. Results: Our study population included 152 (58.0%) males. The mean age was 64.7 years, and the plasma FGF23 concentration was 347.5±549.6 pg/mL (mean±SD). ICAS only, ECAS only, and both ICAS and ECAS were present in 31.2% (n=82), 4.9% (n=13), and 6.8% (n=18) of the subjects, respectively. In multivariate binary and ordinal logistic analyses, after adjusting for sex, age, and variables for which p<0.1 in the univariate analysis, the plasma FGF23 concentration (per 100 pg/mL) was positively correlated with the presence of ICAS [odds ratio (OR)=1.07, 95% CI=1.00-1.15, p=0.039], burden of ICAS (OR=1.09, 95% CI=1.04-1.15, p=0.001), and burden of ECAS (OR=1.06, 95% CI=1.00-1.12, p=0.038), but it was not significantly related to the presence of ECAS (OR=1.05, 95% CI=0.99-1.12, p=0.073). Conclusions: The plasma FGF23 may be a potential biomarker for cerebral atherosclerosis, particularly the presence and burden of ICAS in stroke patients. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Korean Neurological Association | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL NEUROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Plasma Fibroblast Growth Factor 23 Concentration Is Associated With Intracranial Cerebral Atherosclerosis in Acute Ischemic Stroke Patients | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurology (신경과학교실) | - |
dc.contributor.googleauthor | Yoonkyung Chang | - |
dc.contributor.googleauthor | Jinkwon Kim | - |
dc.contributor.googleauthor | Ho Geol Woo | - |
dc.contributor.googleauthor | Dong Ryeol Ryu | - |
dc.contributor.googleauthor | Hyung Jung Oh | - |
dc.contributor.googleauthor | Tae Jin Song | - |
dc.identifier.doi | 10.3988/jcn.2020.16.1.29 | - |
dc.contributor.localId | A01012 | - |
dc.relation.journalcode | J01327 | - |
dc.identifier.eissn | 2005-5013 | - |
dc.identifier.pmid | 31942755 | - |
dc.subject.keyword | Klotho | - |
dc.subject.keyword | cerebral atherosclerosis | - |
dc.subject.keyword | fibroblast growth factor 23 | - |
dc.subject.keyword | intracranial atherosclerosis | - |
dc.contributor.alternativeName | Kim, Jin Kwon | - |
dc.contributor.affiliatedAuthor | 김진권 | - |
dc.citation.volume | 16 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 29 | - |
dc.citation.endPage | 36 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL NEUROLOGY, Vol.16(1) : 29-36, 2020-01 | - |
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