Cited 37 times in
Effect of Dexmedetomidine on Acute Kidney Injury After Aortic Surgery: A Single-Centre, Placebo-Controlled, Randomised Controlled Trial
DC Field | Value | Language |
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dc.contributor.author | 곽영란 | - |
dc.contributor.author | 소사라 | - |
dc.contributor.author | 송종욱 | - |
dc.contributor.author | 심재광 | - |
dc.date.accessioned | 2020-06-17T00:23:27Z | - |
dc.date.available | 2020-06-17T00:23:27Z | - |
dc.date.issued | 2020-04 | - |
dc.identifier.issn | 0007-0912 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/175946 | - |
dc.description.abstract | Background: Acute kidney injury (AKI) is a frequent and serious complication after aortic surgery requiring cardiopulmonary bypass (CPB). Dexmedetomidine, a selective α-2 adrenoreceptor agonist, may reduce AKI because of its sympatholytic and anti-inflammatory effects against ischaemia-reperfusion injury. We investigated the effect of dexmedetomidine administration on AKI after aortic surgery requiring CPB in a placebo-controlled randomised controlled trial. Methods: A total of 108 patients were randomly assigned to an infusion of dexmedetomidine or saline at a rate of 0.4 μg kg-1 h-1 for 24 h starting after anaesthetic induction. The primary outcome was the incidence of AKI, as defined by the Kidney Disease: Improving Global Outcomes (KDIGO) criteria. The secondary outcomes included delirium and major morbidity. Safety outcomes were drug-related adverse events (bradycardia, hypotension). Results: AKI occurred in 7/54 (13%) subjects randomised to dexmedetomidine, compared with 17/54 (31%) subjects randomised to saline infusion (odds ratio=0.32; 95% confidence interval [CI], 0.12-0.86; P=0.026). Secondary outcomes, including stroke, mortality, and delirium, were similar between subjects randomised to dexmedetomidine (16/54 [30%] or saline control (22 [41%]; odds ratio=0.61 [95% CI, 0.28-1.36]). The incidence of bradycardia and hypotension was similar between groups (14/54 (26%) vs. 17/54 (32%) (odds ratio:0.76 (95%CI:0.33-1.76) and 29/54 (54%) vs. 36/54 (67%) (odds ratio:0.58 (95%CI:0.27-1.26), respectively). The length of hospital stay was shorter in the dexmedetomidine group (12 [10-17] days) vs saline control (15 [11-21] days; P=0.039). Conclusions: Pre-emptive dexmedetomidine administration for 24 h starting after induction of anaesthesia reduced the incidence of AKI after aortic surgery requiring CPB, without any untoward side-effects related to its sedative or sympatholytic effects. Clinical trial registration: NCT02607163 (www.ClinicalTrials.gov). | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Oxford University Press | - |
dc.relation.isPartOf | BRITISH JOURNAL OF ANAESTHESIA | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Effect of Dexmedetomidine on Acute Kidney Injury After Aortic Surgery: A Single-Centre, Placebo-Controlled, Randomised Controlled Trial | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) | - |
dc.contributor.googleauthor | Sarah Soh | - |
dc.contributor.googleauthor | Jae-Kwang Shim | - |
dc.contributor.googleauthor | Jong-Wook Song | - |
dc.contributor.googleauthor | Jae-Chan Bae | - |
dc.contributor.googleauthor | Young-Lan Kwak | - |
dc.identifier.doi | 10.1016/j.bja.2019.12.036 | - |
dc.contributor.localId | A00172 | - |
dc.contributor.localId | A01960 | - |
dc.contributor.localId | A02060 | - |
dc.contributor.localId | A02205 | - |
dc.relation.journalcode | J00405 | - |
dc.identifier.eissn | 1471-6771 | - |
dc.identifier.pmid | 32007239 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0007091220300015 | - |
dc.subject.keyword | acute kidney injury | - |
dc.subject.keyword | aorta | - |
dc.subject.keyword | cardiovascular disease | - |
dc.subject.keyword | dexmedetomidine | - |
dc.subject.keyword | postoperative complications | - |
dc.contributor.alternativeName | Kwak, Young Lan | - |
dc.contributor.affiliatedAuthor | 곽영란 | - |
dc.contributor.affiliatedAuthor | 소사라 | - |
dc.contributor.affiliatedAuthor | 송종욱 | - |
dc.contributor.affiliatedAuthor | 심재광 | - |
dc.citation.volume | 124 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 386 | - |
dc.citation.endPage | 394 | - |
dc.identifier.bibliographicCitation | BRITISH JOURNAL OF ANAESTHESIA, Vol.124(4) : 386-394, 2020-04 | - |
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