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Microneedle Drug Eluting Balloon for Enhanced Drug Delivery to Vascular Tissue

Authors
 KangJu Lee  ;  JiYong Lee  ;  Seul Gee Lee  ;  SeungHyun Park  ;  Da Som Yang  ;  Jung-Jae Lee  ;  Ali Khademhosseini  ;  Jung Sun Kim  ;  WonHyoung Ryu 
Citation
 JOURNAL OF CONTROLLED RELEASE, Vol.321 : 174-183, 2020-05 
Journal Title
 JOURNAL OF CONTROLLED RELEASE 
ISSN
 0168-3659 
Issue Date
2020-05
Keywords
Conformal transfer molding ; Drug eluting balloon ; Endovascular drug delivery ; Microneedle ; Vascular disease
Abstract
High rates of restenosis and neointimal formation have driven increasing interest in the application of drug eluting balloons (DEB) as counteractive measures for intraluminal drug delivery. The use of DEBs eliminates the need for stents so that serious side effects including in-stent restenosis and stent thrombosis can be avoided and long-term medication of anti-platelet agent is not needed. Despite their benefits, DEBs have poor drug delivery efficiency due to short balloon inflation times (30-60 s) that limit the passive drug diffusion from the balloon surface to the luminal lesion. To increase drug delivery efficiency, a microneedle DEB (MNDEB) was developed by a conformal transfer molding process using a thin polydimethylsiloxane mold bearing a negative array of MNs of 200 μm in height. A MN array composed of UV curable resin was formed onto the surface of DEB, and drugs were coated onto the structure. The mechanical properties of the MN array were investigated and MN penetration into luminal vasculature was confirmed in vivo. An increase in drug delivery efficiency compared to a standard DEB was demonstrated in an in vivo test in a rabbit aorta. Finally, the superior therapeutic efficacy of MNDEBs was evaluated using an atherosclerosis rabbit model.
Full Text
https://www.sciencedirect.com/science/article/pii/S0168365920300894
DOI
10.1016/j.jconrel.2020.02.012
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jung Sun(김중선) ORCID logo https://orcid.org/0000-0003-2263-3274
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/175944
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