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Optimization of Medial Forebrain Bundle Stimulation Parameters for Operant Conditioning of Rats

Authors
 Chanho Kong  ;  Jaewoo Shin  ;  Chin-Su Koh  ;  Jihyeon Lee  ;  Min-Sik Yoon  ;  Yoon Kyung Cho  ;  Soonyoung Kim  ;  Sang Beom Jun  ;  Hyun Ho Jung  ;  Jin Woo Chang 
Citation
 STEREOTACTIC AND FUNCTIONAL NEUROSURGERY, Vol.97(1) : 1-9, 2019-05 
Journal Title
 STEREOTACTIC AND FUNCTIONAL NEUROSURGERY 
ISSN
 1011-6125 
Issue Date
2019-05
MeSH
Animals ; Conditioning, Operant / physiology* ; Electric Stimulation / methods ; Locomotion / physiology ; Male ; Medial Forebrain Bundle / physiology* ; Rats ; Rats, Sprague-Dawley ; Reward ; Self Stimulation / physiology*
Keywords
Deep brain stimulation ; Intracranial self-stimulation ; Medial forebrain bundle ; Operant conditioning ; Stimulation parameter
Abstract
Background: The medial forebrain bundle (MFB) is involved in the integration of pleasure and reward. Previous studies have used various stimulation parameters for operant conditioning, though the effectiveness of these parameters has not been systematically studied. Objectives: The purpose of the present study was to investigate the optimal MFB stimulation parameters for controlling the conditioned behavior of rats. Methods: We evaluated four factors, including intensity, frequency, pulse duration, and train duration, to determine the effect of each on lever pressure applied by animals. We further compared burst and tonic stimulation in terms of learning and performance abilities. Results: The number of lever presses increased with each factor. Animals in the burst stimulation group exhibited more lever presses. Furthermore, the average speed in the maze among burst stimulation group subjects was higher. Conclusion: We determined the optimal parameters for movement control of animals in operant conditioning and locomotor tasks by adjusting various electrical stimulation parameters. Our results reveal that a burst stimulation is more effective than a tonic stimulation for increasing the moving speed and number of lever presses. The use of this stimulation technique also allowed us to minimize the training required to control animal behavior.
Full Text
https://www.karger.com/Article/FullText/497151
DOI
10.1159/000497151
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Koh, Chin Su(고진수)
Kong, Chanho(공찬호)
Shin, Jaewoo(신재우) ORCID logo https://orcid.org/0000-0002-6335-1292
Chang, Jin Woo(장진우) ORCID logo https://orcid.org/0000-0002-2717-0101
Jung, Hyun Ho(정현호)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/175895
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