Cited 25 times in
Anti-Smith Antibody Is Associated With Disease Activity in Patients With New-Onset Systemic Lupus Erythematosus
DC Field | Value | Language |
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dc.contributor.author | 박용범 | - |
dc.contributor.author | 송정식 | - |
dc.contributor.author | 안성수 | - |
dc.contributor.author | 유주영 | - |
dc.contributor.author | 이상원 | - |
dc.contributor.author | 정승민 | - |
dc.date.accessioned | 2020-06-04T08:48:49Z | - |
dc.date.available | 2020-06-04T08:48:49Z | - |
dc.date.issued | 2019-11 | - |
dc.identifier.issn | 0172-8172 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/175891 | - |
dc.description.abstract | Although anti-Smith (Sm) antibody is a highly specific antibody for systemic lupus erythematosus (SLE), the significance of anti-Sm antibody in patients with SLE is unclear. This study aimed to evaluate the association between anti-Sm antibodies and disease activity in patients with new-onset SLE. We included patients who were tested for anti-Sm antibodies at SLE diagnosis and within 12 months after diagnosis. SLE disease activity index (SLEDAI) was obtained at the time of the anti-Sm antibody test. The baseline disease activity was compared between patients with and without anti-Sm antibodies. The longitudinal association between disease activity and anti-Sm antibodies was also evaluated in total patients and in those with anti-Sm antibodies. Among 92 patients who were tested for anti-Sm antibodies at SLE diagnosis, 67 and another 67 patients were followed up for the presence of anti-Sm antibodies at 6 and 12 months, respectively. Although the baseline SLEDAI was comparable in patients with and without anti-Sm antibodies, the serum level of anti-Sm antibody was significantly correlated with SLEDAI (P = 0.003). At 12 months, anti-Sm antibody positivity was associated with higher SLEDAI and anti-dsDNA titer (P = 0.002, both). In addition, the changes in anti-Sm antibody titer over 12 months were correlated with the alterations in SLEDAI (P = 0.029).Anti-Sm antibody was associated with the baseline disease activity and the alteration of disease activity in patients with new-onset SLE. Monitoring of anti-Sm antibody titer may help assess the disease activity in SLE. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Springer International | - |
dc.relation.isPartOf | RHEUMATOLOGY INTERNATIONAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Antibodies, Antinuclear / blood* | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lupus Erythematosus, Systemic / blood | - |
dc.subject.MESH | Lupus Erythematosus, Systemic / diagnosis* | - |
dc.subject.MESH | Lupus Erythematosus, Systemic / immunology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Severity of Illness Index | - |
dc.subject.MESH | Young Adult | - |
dc.title | Anti-Smith Antibody Is Associated With Disease Activity in Patients With New-Onset Systemic Lupus Erythematosus | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Sung Soo Ahn | - |
dc.contributor.googleauthor | Seung Min Jung | - |
dc.contributor.googleauthor | Juyoung Yoo | - |
dc.contributor.googleauthor | Sang-Won Lee | - |
dc.contributor.googleauthor | Jason Jungsik Song | - |
dc.contributor.googleauthor | Yong-Beom Park | - |
dc.identifier.doi | 10.1007/s00296-019-04445-y | - |
dc.contributor.localId | A01579 | - |
dc.contributor.localId | A02057 | - |
dc.contributor.localId | A02233 | - |
dc.contributor.localId | A05157 | - |
dc.contributor.localId | A02824 | - |
dc.contributor.localId | A05179 | - |
dc.relation.journalcode | J02625 | - |
dc.identifier.eissn | 1437-160X | - |
dc.identifier.pmid | 31552434 | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs00296-019-04445-y | - |
dc.subject.keyword | Anti-Smith antibody | - |
dc.subject.keyword | Disease activity | - |
dc.subject.keyword | Systemic lupus erythematosus | - |
dc.subject.keyword | Systemic lupus erythematosus disease activity index | - |
dc.contributor.alternativeName | Park, Yong Beom | - |
dc.contributor.affiliatedAuthor | 박용범 | - |
dc.contributor.affiliatedAuthor | 송정식 | - |
dc.contributor.affiliatedAuthor | 안성수 | - |
dc.contributor.affiliatedAuthor | 유주영 | - |
dc.contributor.affiliatedAuthor | 이상원 | - |
dc.contributor.affiliatedAuthor | 정승민 | - |
dc.citation.volume | 39 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 1937 | - |
dc.citation.endPage | 1944 | - |
dc.identifier.bibliographicCitation | RHEUMATOLOGY INTERNATIONAL, Vol.39(11) : 1937-1944, 2019-11 | - |
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