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Relationship Between Natural Killer Cell Activity and Glucose Control in Patients With Type 2 Diabetes and Prediabetes

DC FieldValueLanguage
dc.contributor.author강신애-
dc.contributor.author김정혜-
dc.contributor.author남지선-
dc.contributor.author박가희-
dc.contributor.author박종숙-
dc.contributor.author안철우-
dc.contributor.author이상배-
dc.date.accessioned2020-06-04T08:41:04Z-
dc.date.available2020-06-04T08:41:04Z-
dc.date.issued2019-09-
dc.identifier.issn2040-1116-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/175844-
dc.description.abstractAims/introduction: Natural killer (NK) cells are cytotoxic lymphocytes critical to human immunity. Previous studies showed correlations between NK cell function and blood glucose concentrations. The purpose of the present study was to assess the NK cell activity and various metabolic parameters in people with type 2 diabetes, prediabetes and normal glucose tolerance. Materials and methods: A total of 49 participants were enrolled in the study. Anthropometric and biochemical parameters including age, sex, body mass index, smoking status, blood pressure, fasting plasma glucose, C-peptide, insulin, glycated hemoglobin, total cholesterol, triglyceride, high-density lipoprotein cholesterol and low-density lipoprotein cholesterol were assessed. The 75 g oral glucose tolerance test was carried out for 2-h postload glucose level. Homeostatic model assessment was calculated for insulin resistance and β-cell function. NK cell activity was measured by detecting the circulating interferon-gamma level secreted from NK cells. Results: NK cell activity was lower in patients with type 2 diabetes (768.01 ± 650.35) compared with those with prediabetes (2,396.08 ± 653.76, P < 0.001) and normal glucose tolerance (2,435.31 ± 633.22, P < 0.001). In patients with type 2 diabetes, there was a significant inverse linear relationship between NK cell activity and fasting plasma glucose, glycated hemoglobin, and 2-h postload glucose level (all P < 0.001). Multiple regression analysis showed glycated hemoglobin to be an independent predictor of NK cell activity in patients with type 2 diabetes. Conclusions: Compared with individuals with normal glucose tolerance or prediabetes, type 2 diabetes patients have a reduced NK cell activity, and it is significantly related to glucose control.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherAsian Association for the Study of Diabetes and Blackwell Pub. Asia-
dc.relation.isPartOfJOURNAL OF DIABETES INVESTIGATION-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHBiomarkers / analysis*-
dc.subject.MESHBlood Glucose / metabolism*-
dc.subject.MESHCross-Sectional Studies-
dc.subject.MESHDiabetes Mellitus, Type 2 / immunology-
dc.subject.MESHDiabetes Mellitus, Type 2 / metabolism-
dc.subject.MESHDiabetes Mellitus, Type 2 / pathology*-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHGlycated Hemoglobin A / analysis-
dc.subject.MESHHumans-
dc.subject.MESHKiller Cells, Natural / immunology*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPrediabetic State / immunology-
dc.subject.MESHPrediabetic State / metabolism-
dc.subject.MESHPrediabetic State / pathology*-
dc.subject.MESHPrognosis-
dc.titleRelationship Between Natural Killer Cell Activity and Glucose Control in Patients With Type 2 Diabetes and Prediabetes-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorJung Hye Kim-
dc.contributor.googleauthorKahui Park-
dc.contributor.googleauthorSang Bae Lee-
dc.contributor.googleauthorShinae Kang-
dc.contributor.googleauthorJong Suk Park-
dc.contributor.googleauthorChul Woo Ahn-
dc.contributor.googleauthorJi Sun Nam-
dc.identifier.doi10.1111/jdi.13002-
dc.contributor.localIdA00052-
dc.contributor.localIdA05752-
dc.contributor.localIdA05752-
dc.contributor.localIdA01268-
dc.contributor.localIdA01268-
dc.contributor.localIdA05757-
dc.contributor.localIdA05757-
dc.contributor.localIdA01660-
dc.contributor.localIdA01660-
dc.contributor.localIdA02270-
dc.contributor.localIdA02270-
dc.contributor.localIdA02817-
dc.contributor.localIdA02817-
dc.relation.journalcodeJ01377-
dc.identifier.eissn2040-1124-
dc.identifier.pmid30618112-
dc.subject.keywordHyperglycemia-
dc.subject.keywordNatural killer cell activity-
dc.subject.keywordType 2 diabetes mellitus-
dc.contributor.alternativeNameKang, Shin Ae-
dc.contributor.affiliatedAuthor강신애-
dc.contributor.affiliatedAuthor김정혜-
dc.contributor.affiliatedAuthor김정혜-
dc.contributor.affiliatedAuthor남지선-
dc.contributor.affiliatedAuthor남지선-
dc.contributor.affiliatedAuthor박가희-
dc.contributor.affiliatedAuthor박가희-
dc.contributor.affiliatedAuthor박종숙-
dc.contributor.affiliatedAuthor박종숙-
dc.contributor.affiliatedAuthor안철우-
dc.contributor.affiliatedAuthor안철우-
dc.contributor.affiliatedAuthor이상배-
dc.contributor.affiliatedAuthor이상배-
dc.citation.volume10-
dc.citation.number5-
dc.citation.startPage1223-
dc.citation.endPage1228-
dc.identifier.bibliographicCitationJOURNAL OF DIABETES INVESTIGATION, Vol.10(5) : 1223-1228, 2019-09-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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