Cited 49 times in
Relationship Between Natural Killer Cell Activity and Glucose Control in Patients With Type 2 Diabetes and Prediabetes
DC Field | Value | Language |
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dc.contributor.author | 강신애 | - |
dc.contributor.author | 김정혜 | - |
dc.contributor.author | 남지선 | - |
dc.contributor.author | 박가희 | - |
dc.contributor.author | 박종숙 | - |
dc.contributor.author | 안철우 | - |
dc.contributor.author | 이상배 | - |
dc.date.accessioned | 2020-06-04T08:41:04Z | - |
dc.date.available | 2020-06-04T08:41:04Z | - |
dc.date.issued | 2019-09 | - |
dc.identifier.issn | 2040-1116 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/175844 | - |
dc.description.abstract | Aims/introduction: Natural killer (NK) cells are cytotoxic lymphocytes critical to human immunity. Previous studies showed correlations between NK cell function and blood glucose concentrations. The purpose of the present study was to assess the NK cell activity and various metabolic parameters in people with type 2 diabetes, prediabetes and normal glucose tolerance. Materials and methods: A total of 49 participants were enrolled in the study. Anthropometric and biochemical parameters including age, sex, body mass index, smoking status, blood pressure, fasting plasma glucose, C-peptide, insulin, glycated hemoglobin, total cholesterol, triglyceride, high-density lipoprotein cholesterol and low-density lipoprotein cholesterol were assessed. The 75 g oral glucose tolerance test was carried out for 2-h postload glucose level. Homeostatic model assessment was calculated for insulin resistance and β-cell function. NK cell activity was measured by detecting the circulating interferon-gamma level secreted from NK cells. Results: NK cell activity was lower in patients with type 2 diabetes (768.01 ± 650.35) compared with those with prediabetes (2,396.08 ± 653.76, P < 0.001) and normal glucose tolerance (2,435.31 ± 633.22, P < 0.001). In patients with type 2 diabetes, there was a significant inverse linear relationship between NK cell activity and fasting plasma glucose, glycated hemoglobin, and 2-h postload glucose level (all P < 0.001). Multiple regression analysis showed glycated hemoglobin to be an independent predictor of NK cell activity in patients with type 2 diabetes. Conclusions: Compared with individuals with normal glucose tolerance or prediabetes, type 2 diabetes patients have a reduced NK cell activity, and it is significantly related to glucose control. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Asian Association for the Study of Diabetes and Blackwell Pub. Asia | - |
dc.relation.isPartOf | JOURNAL OF DIABETES INVESTIGATION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Biomarkers / analysis* | - |
dc.subject.MESH | Blood Glucose / metabolism* | - |
dc.subject.MESH | Cross-Sectional Studies | - |
dc.subject.MESH | Diabetes Mellitus, Type 2 / immunology | - |
dc.subject.MESH | Diabetes Mellitus, Type 2 / metabolism | - |
dc.subject.MESH | Diabetes Mellitus, Type 2 / pathology* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Glycated Hemoglobin A / analysis | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Killer Cells, Natural / immunology* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Prediabetic State / immunology | - |
dc.subject.MESH | Prediabetic State / metabolism | - |
dc.subject.MESH | Prediabetic State / pathology* | - |
dc.subject.MESH | Prognosis | - |
dc.title | Relationship Between Natural Killer Cell Activity and Glucose Control in Patients With Type 2 Diabetes and Prediabetes | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Jung Hye Kim | - |
dc.contributor.googleauthor | Kahui Park | - |
dc.contributor.googleauthor | Sang Bae Lee | - |
dc.contributor.googleauthor | Shinae Kang | - |
dc.contributor.googleauthor | Jong Suk Park | - |
dc.contributor.googleauthor | Chul Woo Ahn | - |
dc.contributor.googleauthor | Ji Sun Nam | - |
dc.identifier.doi | 10.1111/jdi.13002 | - |
dc.contributor.localId | A00052 | - |
dc.contributor.localId | A05752 | - |
dc.contributor.localId | A01268 | - |
dc.contributor.localId | A05757 | - |
dc.contributor.localId | A01660 | - |
dc.contributor.localId | A02270 | - |
dc.contributor.localId | A02817 | - |
dc.relation.journalcode | J01377 | - |
dc.identifier.eissn | 2040-1124 | - |
dc.identifier.pmid | 30618112 | - |
dc.subject.keyword | Hyperglycemia | - |
dc.subject.keyword | Natural killer cell activity | - |
dc.subject.keyword | Type 2 diabetes mellitus | - |
dc.contributor.alternativeName | Kang, Shin Ae | - |
dc.contributor.affiliatedAuthor | 강신애 | - |
dc.contributor.affiliatedAuthor | 김정혜 | - |
dc.contributor.affiliatedAuthor | 남지선 | - |
dc.contributor.affiliatedAuthor | 박가희 | - |
dc.contributor.affiliatedAuthor | 박종숙 | - |
dc.contributor.affiliatedAuthor | 안철우 | - |
dc.contributor.affiliatedAuthor | 이상배 | - |
dc.citation.volume | 10 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1223 | - |
dc.citation.endPage | 1228 | - |
dc.identifier.bibliographicCitation | JOURNAL OF DIABETES INVESTIGATION, Vol.10(5) : 1223-1228, 2019-09 | - |
dc.identifier.rimsid | 64755 | - |
dc.type.rims | ART | - |
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