Cited 22 times in
The Influence of Body Mass Index at Diagnosis on Cognitive Decline in Parkinson's Disease
DC Field | Value | Language |
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dc.contributor.author | 손영호 | - |
dc.contributor.author | 유한수 | - |
dc.contributor.author | 이필휴 | - |
dc.contributor.author | 정석종 | - |
dc.date.accessioned | 2020-06-04T08:40:46Z | - |
dc.date.available | 2020-06-04T08:40:46Z | - |
dc.date.issued | 2019-10 | - |
dc.identifier.issn | 1738-6586 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/175842 | - |
dc.description.abstract | Background and purpose: Associations between alterations in body mass index (BMI) and cognitive function have been reported in Parkinson's disease (PD). We investigated whether the BMI at a PD diagnosis is associated with cognitive decline and the future development of dementia. Methods: We recruited 70 patients with de novo PD who underwent neuropsychological testing every 3 years and were followed up for more than 6 years. We classified patients into the following three groups based on their BMI at the diagnosis: under-/normal weight (n=21), overweight (n=22), and obese (n=27). We evaluated differences in the rate of cognitive decline over time among the groups using linear mixed models and the conversion rate to dementia using survival analysis. Results: The obese patients with PD showed a slower deterioration of global cognitive function as well as language and memory functions than did the under-/normal-weight group during the 6-year follow-up. The three BMI groups showed different rates of conversion to dementia (log-rank test: p=0.026). The combined overweight and obese group showed a lower risk of developing dementia compared with the under-/normal-weight group (hazard ratio= 0.36, 95% CI=0.12-0.82, p=0.046). Conclusions: We have demonstrated that a higher-than-normal BMI at the time of a PD diagnosis has a protective effect against the deterioration of cognitive function and the conversion to dementia. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Korean Neurological Association | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL NEUROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | The Influence of Body Mass Index at Diagnosis on Cognitive Decline in Parkinson's Disease | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Neurology (신경과학교실) | - |
dc.contributor.googleauthor | Han Soo Yoo | - |
dc.contributor.googleauthor | Seok Jong Chung | - |
dc.contributor.googleauthor | Phil Hyu Lee | - |
dc.contributor.googleauthor | Young H Sohn | - |
dc.contributor.googleauthor | Suk Yun Kang | - |
dc.identifier.doi | 10.3988/jcn.2019.15.4.517 | - |
dc.contributor.localId | A01982 | - |
dc.contributor.localId | A05367 | - |
dc.contributor.localId | A03270 | - |
dc.contributor.localId | A04666 | - |
dc.relation.journalcode | J01327 | - |
dc.identifier.eissn | 2005-5013 | - |
dc.identifier.pmid | 31591841 | - |
dc.subject.keyword | Parkinson disease | - |
dc.subject.keyword | Parkinson's disease dementia | - |
dc.subject.keyword | body mass index | - |
dc.subject.keyword | cognitive decline | - |
dc.subject.keyword | neuropsychological test | - |
dc.contributor.alternativeName | Sohn, Young Ho | - |
dc.contributor.affiliatedAuthor | 손영호 | - |
dc.contributor.affiliatedAuthor | 유한수 | - |
dc.contributor.affiliatedAuthor | 이필휴 | - |
dc.contributor.affiliatedAuthor | 정석종 | - |
dc.citation.volume | 15 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 517 | - |
dc.citation.endPage | 526 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL NEUROLOGY, Vol.15(4) : 517-526, 2019-10 | - |
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