Cited 2 times in
Clinical Implication of Renal Dysfunction During the Clinical Course in Patients With Paroxysmal Nocturnal Hemoglobinuria: A Longitudinal Analysis
DC Field | Value | Language |
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dc.contributor.author | 김진석 | - |
dc.contributor.author | 정준원 | - |
dc.date.accessioned | 2020-06-04T08:36:07Z | - |
dc.date.available | 2020-06-04T08:36:07Z | - |
dc.date.issued | 2019-10 | - |
dc.identifier.issn | 0939-5555 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/175808 | - |
dc.description.abstract | Although renal dysfunction at the time of diagnosis of paroxysmal nocturnal hemoglobinuria (PNH) is a risk factor for mortality, subsequent renal events can occur. The objective of this study was to identify clinical implication of renal dysfunction occurring during the disease course in PNH patients. One hundred one patients with a granulocyte clone size of > 10% were enrolled. Renal events were observed in 55 (54.5%) patients during a median follow-up of 94.2 months. Median time to first renal event from diagnosis of PNH was 79.3 months. Thromboembolism (TE) event and recurrent TE events were observed in 25 (24.8%) and 8 (7.9%) patients, respectively. The rate of recurrent TE was significantly higher in patients with renal events ≥ 2 compared with that in patients with renal event ≤ 1 (18.8% vs. 2.9%; P = 0.012). The rate of recurrent TE was significantly higher in patients with chronic kidney disease (CKD) + acute kidney disease (AKD) compared with the rest of the patients (27.3% vs. 5.6%; P = 0.040). CKD+AKD was the only independent risk factor for OS in multivariate analysis (hazard ratio 7.95, 95% CI 1.24-51.15, P = 0.029). Therefore, close monitoring of renal events in PNH patients during the entire clinical course is essential. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Springer International | - |
dc.relation.isPartOf | ANNALS OF HEMATOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Acute Kidney Injury* / epidemiology | - |
dc.subject.MESH | Acute Kidney Injury* / etiology | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Hemoglobinuria, Paroxysmal* / complications | - |
dc.subject.MESH | Hemoglobinuria, Paroxysmal* / epidemiology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Longitudinal Studies | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Renal Insufficiency, Chronic* / epidemiology | - |
dc.subject.MESH | Renal Insufficiency, Chronic* / etiology | - |
dc.subject.MESH | Thromboembolism / epidemiology | - |
dc.subject.MESH | Thromboembolism / etiology | - |
dc.title | Clinical Implication of Renal Dysfunction During the Clinical Course in Patients With Paroxysmal Nocturnal Hemoglobinuria: A Longitudinal Analysis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Jin Seok Kim | - |
dc.contributor.googleauthor | June-Won Cheong | - |
dc.contributor.googleauthor | Yeung-Chul Mun | - |
dc.contributor.googleauthor | Jun Ho Jang | - |
dc.contributor.googleauthor | Deog-Yeon Jo | - |
dc.contributor.googleauthor | Jong Wook Lee | - |
dc.contributor.googleauthor | Aplastic Anemia Working Party of the Korean Society of Hematology | - |
dc.identifier.doi | 10.1007/s00277-019-03735-6 | - |
dc.contributor.localId | A01017 | - |
dc.contributor.localId | A03729 | - |
dc.relation.journalcode | J00161 | - |
dc.identifier.eissn | 1432-0584 | - |
dc.identifier.pmid | 31256219 | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs00277-019-03735-6 | - |
dc.subject.keyword | Mortality | - |
dc.subject.keyword | Paroxysmal nocturnal hemoglobinuria | - |
dc.subject.keyword | Renal dysfunction | - |
dc.subject.keyword | Thromboembolism | - |
dc.contributor.alternativeName | Kim, Jin Seok | - |
dc.contributor.affiliatedAuthor | 김진석 | - |
dc.contributor.affiliatedAuthor | 정준원 | - |
dc.citation.volume | 98 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 2273 | - |
dc.citation.endPage | 2281 | - |
dc.identifier.bibliographicCitation | ANNALS OF HEMATOLOGY, Vol.98(10) : 2273-2281, 2019-10 | - |
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