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Evaluation of pharmacokinetic interactions between amoxicillin, clarithromycin, and the potassium-competitive acid blocker YH4808 in healthy subjects

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dc.contributor.author홍태곤-
dc.contributor.author박민수-
dc.contributor.author김춘옥-
dc.date.accessioned2020-05-14T02:20:30Z-
dc.date.available2020-05-14T02:20:30Z-
dc.date.issued2020-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/175752-
dc.description.abstractYH4808 is a novel potassium-competitive acid blocker that was developed as a therapeutic agent for gastric acid-related diseases; it may replace proton pump inhibitors, which are widely used in combination with amoxicillin and clarithromycin for Helicobacter pylori eradication. We compared the pharmacokinetic (PK) profiles and safety of amoxicillin, clarithromycin, and YH4808 used as monotherapies or in combination for evaluating potential drug interactions. An open-label, randomized, single-dose, Latin-square (4 × 4) crossover study was conducted in 32 healthy Korean volunteers. Subjects were randomly assigned to one of the 4 treatment sequences that consisted of 4 periods separated by 21-day washout intervals. PK parameters of YH4808, amoxicillin and clarithromycin administered in combination were compared with those of the respective monotherapies. The geometric mean ratios of the maximum concentration (Cmax) and the area under the time-concentration curve from time zero to time of the last quantifiable concentration (AUClast) of YH4808 increased during the triple therapy by 48.6% and 29.1%, respectively. Similarly, the Cmax and AUClast of M3 (active metabolite of YH4808) increased by 23.3% and 16.0%, respectively. The Cmax and AUClast of clarithromycin increased by 27.4% and 30.5%, and those of 14-hydroxyclarithromycin were increased by 23.1% and 32.4%, respectively. The corresponding amoxicillin values decreased during the triple therapy by 21.5% and 15.6%, respectively. There was no clinically significant change in safety assessment related to either monotherapies or triple therapy. In conclusion, amoxicillin, clarithromycin and YH4808 administered as triple therapy did not exhibit significant PK interactions and were not associated with safety issues.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfTransl Clin Pharmacol-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleEvaluation of pharmacokinetic interactions between amoxicillin, clarithromycin, and the potassium-competitive acid blocker YH4808 in healthy subjects-
dc.typeArticle-
dc.contributor.collegeOthers-
dc.contributor.departmentSeverance Hospital (세브란스병원)-
dc.contributor.googleauthorWoo Yul Lee-
dc.contributor.googleauthorEunSil Oh-
dc.contributor.googleauthorMengqi Cui-
dc.contributor.googleauthorChoon Ok Kim-
dc.contributor.googleauthorYeji Lim-
dc.contributor.googleauthorHunam Kim-
dc.contributor.googleauthorHyeonsoo Park-
dc.contributor.googleauthorSukyong Yoon-
dc.contributor.googleauthorMin Soo Park-
dc.contributor.googleauthorTaegon Hong-
dc.identifier.doi10.12793/tcp.2020.28.e5-
dc.contributor.localIdA05194-
dc.contributor.localIdA01468-
dc.contributor.localIdA01468-
dc.contributor.localIdA04735-
dc.contributor.localIdA04735-
dc.identifier.pmid32274381-
dc.subject.keywordDrug interactions-
dc.subject.keywordHelicobacter pylori-
dc.subject.keywordPharmacokinetics-
dc.subject.keywordPotassium-competitive acid blocker-
dc.subject.keywordTriple therapy-
dc.contributor.alternativeNameHong, Tae Gon-
dc.contributor.affiliatedAuthor홍태곤-
dc.contributor.affiliatedAuthor박민수-
dc.contributor.affiliatedAuthor박민수-
dc.contributor.affiliatedAuthor김춘옥-
dc.contributor.affiliatedAuthor김춘옥-
dc.citation.volume28-
dc.citation.number1-
dc.citation.startPage55-
dc.citation.endPage65-
dc.identifier.bibliographicCitationTransl Clin Pharmacol, Vol.28(1) : 55-65, 2020-
Appears in Collections:
7. Others (기타) > Others (기타) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers

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