Cited 13 times in
Correlation Analysis and Prognostic Impact of (18)F-FDG PET and Excision Repair Cross-Complementation Group 1 (ERCC-1) Expression in Non-Small Cell Lung Cancer
DC Field | Value | Language |
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dc.contributor.author | 이충근 | - |
dc.contributor.author | 정용휴 | - |
dc.contributor.author | 차종태 | - |
dc.contributor.author | 이정원 | - |
dc.contributor.author | 윤미진 | - |
dc.contributor.author | 조응혁 | - |
dc.contributor.author | 황상현 | - |
dc.date.accessioned | 2020-04-16T02:27:04Z | - |
dc.date.available | 2020-04-16T02:27:04Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1869-3474 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/175687 | - |
dc.description.abstract | PURPOSE: The aim of this study was to determine the relationship between [(18)]-2-fluoro-2-deoxy-D-glucose (FDG) uptake and excision repair cross-complementation group 1 (ERCC-1) expression and to evaluate the prognostic effect of these two factors in resectable non-small cell lung cancer (NSCLC) patients. METHODS: We retrospectively reviewed 212 patients with resectable NSCLC who underwent FDG positron emission tomography/computed tomography (PET/CT) scan for cancer staging and ERCC-1 expression analysis between January 2008 to December 2011. All patients were then followed-up for survival analysis. Semiquantitative evaluation of ERCC-1 was performed with the H-scoring system and was correlated with maximum standardized uptake value (SUVmax) of NSCLC. Univariate and multivariate analyses were performed to evaluate for FDG uptake and ERCC-1 expression predicting overall survival. RESULTS: In 212 patients (139 male, median age 68 ± 9.11), 112 patients had ERCC-positive tumors and 100 patients had ERCC-negative tumors. There was no significant difference in SUVmax between ERCC-1-positive tumors (8.02 ± 5.40) and ERCC-1-negative tumors (7.57 ± 6.56, p = 0.584). All patients were followed-up for a median of 40.5 months (95 % confidence interval [CI], 38.5-42.2 months). Univariate analysis and multivariate analysis for all patients showed that both ERCC-1 expression (hazard ratio [HR], 2.78; 95 % CI, 1.20-6.47) and FDG uptake (HR, 4.50; 95 % CI, 2.07-9.77) independently predicted overall survival. CONCLUSIONS: We have found no statistical correlation between FDG uptake and ERCC-1 expression in NSCLC. However, both higher FDG uptake and positive ERCC-1 expression are independent predictive markers of prognosis, suggesting that both should be obtained during patient workup. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | Korean | - |
dc.publisher | Korean Society of Nuclear Medicine | - |
dc.relation.isPartOf | NUCLEAR MEDICINE AND MOLECULAR IMAGING | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Correlation Analysis and Prognostic Impact of (18)F-FDG PET and Excision Repair Cross-Complementation Group 1 (ERCC-1) Expression in Non-Small Cell Lung Cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Yong Hyu Jeong | - |
dc.contributor.googleauthor | Choong-kun Lee | - |
dc.contributor.googleauthor | Kwanhyeong Jo | - |
dc.contributor.googleauthor | Sang Hyun Hwang | - |
dc.contributor.googleauthor | Jongtae Cha | - |
dc.contributor.googleauthor | Jeong Won Lee | - |
dc.contributor.googleauthor | Mijin Yun | - |
dc.contributor.googleauthor | Arthur Cho | - |
dc.identifier.doi | 10.1007/s13139-014-0304-2 | - |
dc.contributor.localId | A03259 | - |
dc.contributor.localId | A05554 | - |
dc.contributor.localId | A04801 | - |
dc.contributor.localId | A03117 | - |
dc.contributor.localId | A02550 | - |
dc.contributor.localId | A03887 | - |
dc.relation.journalcode | J02382 | - |
dc.identifier.eissn | 1869-3482 | - |
dc.identifier.pmid | 26085855 | - |
dc.subject.keyword | ERCC | - |
dc.subject.keyword | FDG | - |
dc.subject.keyword | NSCLC | - |
dc.subject.keyword | PET/CT | - |
dc.subject.keyword | Prognosis | - |
dc.contributor.alternativeName | Lee, Choong-kun | - |
dc.contributor.affiliatedAuthor | 이충근 | - |
dc.contributor.affiliatedAuthor | 정용휴 | - |
dc.contributor.affiliatedAuthor | 차종태 | - |
dc.contributor.affiliatedAuthor | 이정원 | - |
dc.contributor.affiliatedAuthor | 윤미진 | - |
dc.contributor.affiliatedAuthor | 조응혁 | - |
dc.citation.volume | 49 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 108 | - |
dc.citation.endPage | 114 | - |
dc.identifier.bibliographicCitation | NUCLEAR MEDICINE AND MOLECULAR IMAGING, Vol.49(2) : 108-114, 2015 | - |
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