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Emergence of multidrug‑resistant Providencia rettgeri isolates co‑producing NDM‑1 carbapenemase and PER‑1 extended‑spectrum β‑lactamase causing a first outbreak in Korea

DC FieldValueLanguage
dc.contributor.author홍준성-
dc.contributor.author정석훈-
dc.contributor.author이혁민-
dc.date.accessioned2020-04-16T01:35:03Z-
dc.date.available2020-04-16T01:35:03Z-
dc.date.issued2018-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/175681-
dc.description.abstractBACKGROUND: Nosocomial outbreak due to carbapenem-resistant Enterobacteriaceae has become serious challenge to patient treatment and infection control. We describe an outbreak due to a multidrug-resistant Providencia rettgeri from January 2016 to January 2017 at a University Hospital in Seoul, Korea. METHODS: A total of eight non-duplicate P. rettgeri isolates were discovered from urine samples from eight patients having a urinary catheter and admitted in a surgical intensive care unit. The β-lactamase genes were identified using polymerase chain reaction and direct sequencing, and strain typing was done with pulsed-field gel electrophoresis (PFGE). RESULTS: All isolates showed high-level resistance to extended-spectrum cephalosporins, aztreonam, meropenem, ertapenem, ciprofloxacin, and amikacin. They harbored the blaNDM-1 carbapenemase and the blaPER-1 type extended-spectrum β-lactamases genes. PFGE revealed that all isolates from eight patients were closely related strains. CONCLUSIONS: The 13-month outbreak ended following reinforcement of infection control measures, including contact isolation precautions and environmental disinfection. This is the first report of an outbreak of a P. rettgeri clinical isolates co-producing NDM-1 and PER-1 β-lactamase.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherBioMed Central-
dc.relation.isPartOfANNALS OF CLINICAL MICROBIOLOGY AND ANTIMICROBIALS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAnti-Bacterial Agents/pharmacology-
dc.subject.MESHBacterial Proteins/genetics-
dc.subject.MESHDisease Outbreaks*-
dc.subject.MESHDrug Resistance, Multiple, Bacterial/drug effects-
dc.subject.MESHDrug Resistance, Multiple, Bacterial/genetics*-
dc.subject.MESHElectrophoresis, Gel, Pulsed-Field/methods-
dc.subject.MESHEnterobacteriaceae Infections/epidemiology*-
dc.subject.MESHEnterobacteriaceae Infections/microbiology*-
dc.subject.MESHFemale-
dc.subject.MESHGenes, Bacterial/genetics-
dc.subject.MESHHumans-
dc.subject.MESHIntensive Care Units-
dc.subject.MESHMale-
dc.subject.MESHMicrobial Sensitivity Tests-
dc.subject.MESHProvidencia/drug effects-
dc.subject.MESHProvidencia/genetics*-
dc.subject.MESHProvidencia/isolation & purification*-
dc.subject.MESHProvidencia/pathogenicity*-
dc.subject.MESHRepublic of Korea/epidemiology-
dc.subject.MESHUrinary Catheters/microbiology-
dc.subject.MESHUrinary Tract Infections/epidemiology-
dc.subject.MESHUrinary Tract Infections/microbiology-
dc.subject.MESHUrine/microbiology-
dc.subject.MESHbeta-Lactamases/genetics-
dc.titleEmergence of multidrug‑resistant Providencia rettgeri isolates co‑producing NDM‑1 carbapenemase and PER‑1 extended‑spectrum β‑lactamase causing a first outbreak in Korea-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Laboratory Medicine (진단검사의학교실)-
dc.contributor.googleauthorSaeam Shin-
dc.contributor.googleauthorSeok Hoon Jeong-
dc.contributor.googleauthorHyukmin Lee-
dc.contributor.googleauthorJun Sung Hong-
dc.contributor.googleauthorMin‑Jeong Park-
dc.contributor.googleauthorWonkeun Song-
dc.identifier.doi10.1186/s12941-018-0272-y-
dc.contributor.localIdA04438-
dc.contributor.localIdA03619-
dc.contributor.localIdA03619-
dc.contributor.localIdA03286-
dc.contributor.localIdA03286-
dc.relation.journalcodeJ03795-
dc.identifier.eissn1476-0711-
dc.identifier.pmid29728111-
dc.subject.keywordNDM-1-
dc.subject.keywordOutbreak-
dc.subject.keywordPER-1-
dc.subject.keywordProvidencia rettgeri-
dc.subject.keywordUrinary tract infection-
dc.contributor.alternativeNameHong, Jun Sung-
dc.contributor.affiliatedAuthor홍준성-
dc.contributor.affiliatedAuthor정석훈-
dc.contributor.affiliatedAuthor정석훈-
dc.contributor.affiliatedAuthor이혁민-
dc.contributor.affiliatedAuthor이혁민-
dc.citation.volume17-
dc.citation.startPage20-
dc.identifier.bibliographicCitationANNALS OF CLINICAL MICROBIOLOGY AND ANTIMICROBIALS, Vol.17 : 20, 2018-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers

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