0 43

Cited 0 times in

Autophagy induction can regulate skin pigmentation by causing melanosome degradation in keratinocytes and melanocytes

Authors
 Ji Young Kim  ;  Jihee Kim  ;  Yuri Ahn  ;  Eun Jung Lee  ;  Shinwon Hwang  ;  Abdurrahman Almurayshid  ;  Keedon Park  ;  Hwa‐Jee Chung  ;  Heung Jae Kim  ;  Si‐Hyung Lee  ;  Myung‐Shik Lee  ;  Sang Ho Oh 
Citation
 PIGMENT CELL & MELANOMA RESEARCH, : epub., 2019 
Journal Title
 PIGMENT CELL & MELANOMA RESEARCH 
ISSN
 1755-1471 
Issue Date
2019
Keywords
autophagy ; melanocyte ; melanogenesis ; melanosome degradation ; skin pigmentation
Abstract
Autophagy regulates cellular turnover by disassembling unnecessary or dysfunctional constituents. Recent studies demonstrated that autophagy and its regulators play a wide variety of roles in melanocyte biology. Activation of autophagy is known to induce melanogenesis and regulate melanosome biogenesis in melanocytes. Also, autophagy induction was reported to regulate physiologic skin color via melanosome degradation, although the downstream effectors are not yet clarified. To determine the role of autophagy as a melanosome degradation machinery, we administered several autophagy inducers in human keratinocytes and melanocytes. Our results showed that the synthetic autophagy inducer PTPD-12 stimulated autophagic flux in human melanocytes and in keratinocytes containing transferred melanosomes. Increased autophagic flux led to melanosome degradation without affecting the expression of MITF. Furthermore, the color of cell pellets of both melanocytes and keratinocytes was visibly lightened. Inhibition of autophagic flux by chloroquine resulted in marked attenuation of PTPD-12-induced melanosome degradation, whereas the expression of melanogenesis pathway genes and proteins remained unaffected. Taken together, our results suggest that the modulation of autophagy can contribute to the regulation of melanocyte biology and skin pigmentation.
Full Text
https://onlinelibrary.wiley.com/doi/full/10.1111/pcmr.12838
DOI
10.1111/pcmr.12838
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jihee(김지희) ORCID logo https://orcid.org/0000-0002-0047-5941
Oh, Sang Ho(오상호) ORCID logo https://orcid.org/0000-0002-4477-1400
Lee, Myung Shik(이명식) ORCID logo https://orcid.org/0000-0003-3292-1720
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/175678
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse