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The effect of administration of parathyroid hormone (1-34) on sinus bone graft & dental implant in ovariectomized rabbits

 Chugeum Dam  ;  Ui‐Won Jung  ;  Kyeong‐Mee Park  ;  Jisun Huh  ;  Wonse Park 
 CLINICAL ORAL IMPLANTS RESEARCH, Vol.31(3) : 264-273, 2020 
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Animals ; Bone Density ; Cattle ; Female ; Osteoporosis* ; Ovariectomy ; Parathyroid Hormone ; Rabbits ; Teriparatide* ; X-Ray Microtomography
OBJECTIVES: The purpose of this study was to determine the effect of administering intermittent parathyroid hormone 1-34 [teriparatide, (PTH)] on the maxillary sinus lift and bone grafting in osteoporotic rabbits induced by ovariectomy and glucocorticoid. MATERIALS AND METHODS: Ovariectomies were performed on 20 female New Zealand white rabbits that were randomly divided into two groups: (a) the PTH group (n = 10), in which 10 μg kg-1 day-1 PTH was injected subcutaneously 5 days a week for 5 weeks (from 1 week before until 4 weeks after sinus surgery), and (b) the saline group (n = 10), in which saline substituted PTH at the same dose, mode of administration, and duration. Bone grafting with bovine bone mineral was augmented into 13 sinuses, and bone grafts and implants were simultaneously performed in seven sinuses, in both groups. Animals were sacrificed at 4 weeks after surgery. To determine whether PTH was an effective treatment for osteoporosis, we measured the bone mineral density (BMD) of the right femur using micro-computed tomography and performed radiographic and histometric analyses of the maxillary sinus surgery site. The Mann-Whitney test was used for statistical analysis. RESULTS: It was found that BMD increased in the femur, whereas none of the radiographic and histometric parameters differed significantly between the groups in the sinus, while there were large interindividual variations within groups. CONCLUSIONS: These findings suggest that intermittent PTH does not promote new bone formation in the augmented maxillary sinus of ovariectomized rabbits.
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2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Advanced General Dentistry (통합치의학과) > 1. Journal Papers
Yonsei Authors
Park, Wonse(박원서) ORCID logo https://orcid.org/0000-0002-2081-1156
Jung, Ui Won(정의원) ORCID logo https://orcid.org/0000-0001-6371-4172
Huh, Jisun(허지선) ORCID logo https://orcid.org/0000-0001-5514-187X
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