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Influence of dopamine-related genes on craving, impulsivity, and aggressiveness in Korean males with alcohol use disorder

Authors
 Chun Il Park  ;  Hae Won Kim  ;  Syung Shick Hwang  ;  Jee In Kang  ;  Se Joo Kim 
Citation
 EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, : epub., 2019 
Journal Title
 EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE 
ISSN
 0940-1334 
Issue Date
2019
Keywords
Alcohol use disorder ; Craving ; Dopamine-related genes ; Endophenotype ; Genetic association study ; Impulsivity
Abstract
Dopamine is a major neuromodulator that is acutely involved in various cognitive processes, reward-motivated behaviors, and impulsivity. Abnormality in dopaminergic neurotransmission is implicated in the pathophysiology of alcohol use disorder (AUD). The present study examined the genetic influence of dopamine system on problematic drinking, impulsivity, and aggressiveness in a Korean male population with AUD. Five single nucleotide polymorphisms (SNPs) (rs4532 in DRD1, rs2283265 in DRD2, rs6280 in DRD3, rs1800497 in ANKK1, and rs4680 in COMT) and a variable number of tandem repeats (VNTRs) in DAT1 in 295 male patients with AUD were genotyped. For AUD-related clinical characteristics, the Alcohol Use Disorders Identification Test and the Obsessive-Compulsive Drinking Scale (OCDS) were used to assess the severity of hazardous drinking and craving symptoms, respectively. Participants also completed the UPPS-P Impulsive Behavior Scale (UPPS-P) and Buss-Perry Aggression Questionnaire (BPAQ). Analyses were performed using R package SNPassoc; statistical significance was set as p < 0.0083 after Bonferroni correction. A significant association was detected between DRD3 SNP rs6280 and OCDS scores. In regard to impulsivity and aggressiveness, rs4532 of DRD1 was significantly associated with UPPS-P score. Also, rs4532 demonstrated a nominally significant association with BPAQ score, although it did not reach statistical significance after correction for multiple comparisons. Results of this study support the idea that genetic variations in the dopamine system may contribute to alcohol cravings and impulsivity in patients with AUD.
Full Text
https://link.springer.com/article/10.1007/s00406-019-01072-3
DOI
10.1007/s00406-019-01072-3
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Medical Education (의학교육학과) > 1. Journal Papers
Yonsei Authors
Kang, Jee In(강지인) ORCID logo https://orcid.org/0000-0002-2818-7183
Kim, Se Joo(김세주) ORCID logo https://orcid.org/0000-0002-5438-8210
Kim, Hae Won(김혜원) ORCID logo https://orcid.org/0000-0002-9321-8361
Park, Chun Il(박천일) ORCID logo https://orcid.org/0000-0003-0119-0443
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/175656
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