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An observational study on long-term renal outcome in patients with chronic hepatitis B treated with tenofovir disoproxil fumarate

DC FieldValueLanguage
dc.contributor.author김도영-
dc.contributor.author김범경-
dc.contributor.author김승업-
dc.contributor.author박준용-
dc.contributor.author안상훈-
dc.contributor.author이혜원-
dc.contributor.author임태섭-
dc.contributor.author전미영-
dc.contributor.author한광협-
dc.contributor.author김범경-
dc.contributor.author김승업-
dc.contributor.author박준용-
dc.contributor.author안상훈-
dc.contributor.author이혜원-
dc.contributor.author임태섭-
dc.contributor.author전미영-
dc.contributor.author한광협-
dc.contributor.author이재승-
dc.date.accessioned2020-04-13T17:01:00Z-
dc.date.available2020-04-13T17:01:00Z-
dc.date.issued2020-
dc.identifier.issn1352-0504-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/175617-
dc.description.abstractIn patients with chronic hepatitis B (CHB), long-term effects of tenofovir disoproxil fumarate (TDF) on renal function have been controversial. This study aimed to analyse the real-world long-term effects of TDF on renal function in Korean patients with CHB. We analysed a cohort of 640 treatment-naïve patients with CHB who were treated with TDF between May 2012 and December 2015 at Severance Hospital, Seoul, Republic of Korea. The mean age was 48.3 years old, and 59.5% were male. The proportions of hypertension and diabetes mellitus (DM) were 11.6% and 14.2%, respectively, and that of liver cirrhosis was 20.8%. During the 5-year follow-up, using a linear mixed model, serum creatinine increased from 0.77 ± 0.01 mg/dL to 0.85 ± 0.02 mg/dL (P < .001), and eGFR decreased from 102.6 ± 0.6 mL/min/1.73 m2 to 93.4 ± 1.4 mL/min/1.73 m2 (P < .001). In subgroup analysis, eGFR was statistically more decreased in patients with age > 60 than ≦60 years old (P = .027), and in patients with diuretic use than without diuretic use (P = .008). In multivariate analysis, the independent risk factors for eGFR decrease > 20% were baseline eGFR < 60mL/min/1.73 m2 (P = .034) and the use of diuretics (P < .001). CHB patients on TDF experienced greater reduction in renal function with age > 60 and with diuretic use compared to those without these characteristics. Baseline eGFR < 60 mL/min/1.73 m2 and use of diuretics were independent risk factors of eGFR decline of more than 20% on TDF therapy.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherBlackwell Scientific Publications-
dc.relation.isPartOfJOURNAL OF VIRAL HEPATITIS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleAn observational study on long-term renal outcome in patients with chronic hepatitis B treated with tenofovir disoproxil fumarate-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorTae Seop Lim-
dc.contributor.googleauthorJae Seung Lee-
dc.contributor.googleauthorBeom Kyung Kim-
dc.contributor.googleauthorHye Won Lee-
dc.contributor.googleauthorMi Young Jeon-
dc.contributor.googleauthorSeung Up Kim-
dc.contributor.googleauthorJun Yong Park-
dc.contributor.googleauthorDo Young Kim-
dc.contributor.googleauthorKwang‐Hyub Han-
dc.contributor.googleauthorSang Hoon Ahn-
dc.identifier.doi10.1111/jvh.13222-
dc.contributor.localIdA00385-
dc.contributor.localIdA00487-
dc.contributor.localIdA00487-
dc.contributor.localIdA00654-
dc.contributor.localIdA00654-
dc.contributor.localIdA01675-
dc.contributor.localIdA01675-
dc.contributor.localIdA02226-
dc.contributor.localIdA02226-
dc.contributor.localIdA03318-
dc.contributor.localIdA03318-
dc.contributor.localIdA03414-
dc.contributor.localIdA03414-
dc.contributor.localIdA05405-
dc.contributor.localIdA05405-
dc.contributor.localIdA04268-
dc.contributor.localIdA04268-
dc.contributor.localIdA00487-
dc.contributor.localIdA00487-
dc.contributor.localIdA00654-
dc.contributor.localIdA00654-
dc.contributor.localIdA01675-
dc.contributor.localIdA01675-
dc.contributor.localIdA02226-
dc.contributor.localIdA02226-
dc.contributor.localIdA03318-
dc.contributor.localIdA03318-
dc.contributor.localIdA03414-
dc.contributor.localIdA03414-
dc.contributor.localIdA05405-
dc.contributor.localIdA05405-
dc.contributor.localIdA04268-
dc.contributor.localIdA04268-
dc.relation.journalcodeJ01928-
dc.identifier.eissn1365-2893-
dc.identifier.pmid31639240-
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/full/10.1111/jvh.13222-
dc.subject.keywordchronic-
dc.subject.keyworddrug-related side effects and adverse reactions-
dc.subject.keywordhepatitis B-
dc.subject.keywordliver-
dc.subject.keywordrenal insufficiency-
dc.subject.keywordtenofovir-
dc.contributor.alternativeNameKim, Do Young-
dc.contributor.affiliatedAuthor김도영-
dc.contributor.affiliatedAuthor김범경-
dc.contributor.affiliatedAuthor김범경-
dc.contributor.affiliatedAuthor김승업-
dc.contributor.affiliatedAuthor김승업-
dc.contributor.affiliatedAuthor박준용-
dc.contributor.affiliatedAuthor박준용-
dc.contributor.affiliatedAuthor안상훈-
dc.contributor.affiliatedAuthor안상훈-
dc.contributor.affiliatedAuthor이혜원-
dc.contributor.affiliatedAuthor이혜원-
dc.contributor.affiliatedAuthor임태섭-
dc.contributor.affiliatedAuthor임태섭-
dc.contributor.affiliatedAuthor전미영-
dc.contributor.affiliatedAuthor전미영-
dc.contributor.affiliatedAuthor한광협-
dc.contributor.affiliatedAuthor한광협-
dc.contributor.affiliatedAuthor김범경-
dc.contributor.affiliatedAuthor김범경-
dc.contributor.affiliatedAuthor김승업-
dc.contributor.affiliatedAuthor김승업-
dc.contributor.affiliatedAuthor박준용-
dc.contributor.affiliatedAuthor박준용-
dc.contributor.affiliatedAuthor안상훈-
dc.contributor.affiliatedAuthor안상훈-
dc.contributor.affiliatedAuthor이혜원-
dc.contributor.affiliatedAuthor이혜원-
dc.contributor.affiliatedAuthor임태섭-
dc.contributor.affiliatedAuthor임태섭-
dc.contributor.affiliatedAuthor전미영-
dc.contributor.affiliatedAuthor전미영-
dc.contributor.affiliatedAuthor한광협-
dc.contributor.affiliatedAuthor한광협-
dc.citation.volume27-
dc.citation.number3-
dc.citation.startPage316-
dc.citation.endPage322-
dc.identifier.bibliographicCitationJOURNAL OF VIRAL HEPATITIS, Vol.27(3) : 316-322, 2020-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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