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Preoperative prognostic nutritional index as an independent prognostic factor for resected ampulla of Vater cancer

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dc.contributor.author강창무-
dc.contributor.author노승윤-
dc.contributor.author이우정-
dc.contributor.author최문석-
dc.contributor.author황호경-
dc.date.accessioned2020-04-13T16:55:33Z-
dc.date.available2020-04-13T16:55:33Z-
dc.date.issued2020-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/175566-
dc.description.abstractINTRODUCTION: Prognostic nutritional index (PNI) reflects the nutritional and immunologic status of the patients. The clinical application of PNI is already well-known in various kinds of solid tumors. However, there is no study investigating the relationship between PNI and oncological outcome of the resected ampulla of Vater (AoV) cancer. MATERIALS AND METHODS: From January 2005 to December 2012, the medical records of patients who underwent pancreaticoduodenectomy for pathologically confirmed AoV cancer were retrospectively reviewed. Long-term oncological outcomes were compared according to the preoperative PNI value. RESULT: A total of 118 patients were enrolled in this study. The preoperative PNI was 46.13±6.63, while the mean disease-free survival was 43.88 months and the mean disease-specific survival was 55.3 months. In the multivariate Cox analysis, initial CA19-9 (p = 0.0399), lymphovascular invasion (p = 0.0031), AJCC 8th N-stage (p = 0.0018), and preoperative PNI (p = 0.0081) were identified as significant prognostic factors for resected AoV cancer. The disease-specific survival was better in the high preoperative PNI group (≤48.85: 40.77 months vs. >48.85: 68.05 months, p = 0.0015). A highly accurate nomogram was developed based on four clinical components to predict the 1, 3, and 5-year disease-specific survival probability (C-index 0.8169, 0.8426, and 0.8233, respectively). CONCLUSION: In resected AoV cancer, preoperative PNI can play a significant role as an independent prognostic factor for predicting disease-specific survival.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherPublic Library of Science-
dc.relation.isPartOfPLOS ONE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titlePreoperative prognostic nutritional index as an independent prognostic factor for resected ampulla of Vater cancer-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학교실)-
dc.contributor.googleauthorYoung Jin Yoo-
dc.contributor.googleauthorChang Moo Kang-
dc.contributor.googleauthorMunseok Choi-
dc.contributor.googleauthorSeung Yoon Rho-
dc.contributor.googleauthorHo Kyung Hwang-
dc.contributor.googleauthorWoo Jung Lee-
dc.contributor.googleauthorEun Wha Kim-
dc.contributor.googleauthorJin Ae Lee-
dc.identifier.doi10.1371/journal.pone.0229597-
dc.contributor.localIdA00088-
dc.contributor.localIdA05469-
dc.contributor.localIdA02993-
dc.contributor.localIdA05885-
dc.contributor.localIdA04497-
dc.relation.journalcodeJ02540-
dc.identifier.eissn1932-6203-
dc.identifier.pmid32126069-
dc.contributor.alternativeNameKang, Chang Moo-
dc.contributor.affiliatedAuthor강창무-
dc.contributor.affiliatedAuthor노승윤-
dc.contributor.affiliatedAuthor이우정-
dc.contributor.affiliatedAuthor최문석-
dc.contributor.affiliatedAuthor황호경-
dc.citation.volume15-
dc.citation.number3-
dc.citation.startPagee0229597-
dc.identifier.bibliographicCitationPLOS ONE, Vol.15(3) : e0229597, 2020-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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