Cited 13 times in
Genomic Signature of the Standardized Uptake Value in 18F-Fluorodeoxyglucose Positron Emission Tomography in Breast Cancer
DC Field | Value | Language |
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dc.contributor.author | 배숭준 | - |
dc.contributor.author | 안성귀 | - |
dc.contributor.author | 정준 | - |
dc.date.accessioned | 2020-04-13T16:55:00Z | - |
dc.date.available | 2020-04-13T16:55:00Z | - |
dc.date.issued | 2020 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/175563 | - |
dc.description.abstract | The standardized uptake value (SUV), an indicator of the degree of glucose uptake in 18F-fluorodeoxyglucose positron emission tomography (FDG-PET), has been used for predicting the clinical behavior of malignant tumors. However, its characteristics have been insufficiently explored at the genomics level. Here, we aim to identify genomic signatures reflecting prognostic SUV characteristics in breast cancer (BRC). Through integrative genomic profiling of 3710 BRC patients, including 254 patients who underwent preoperative FDG-PET, we identified an SUV signature, which showed independent clinical utility for predicting BRC prognosis (hazard ratio [HR] 1.27, 95% confidence interval [CI] = 1.12 to 1.45, p = 2.23 × 10-4). The risk subgroups classified by the signature exhibited mutually exclusive mutation patterns of TP53 and PIK3CA and showed significantly different responsiveness to immunotherapy. Experimental assays revealed that a signaling axis defined by TP53-FOXM1 and its downstream effectors in glycolysis-gluconeogenesis, including LDHA, might be important mediators in the FDG-PET process. Our molecular characterizations support an understanding of glucose metabolism and poor prognosis in BRC with a high SUV, utilizable in clinical practice to assist other diagnostic tools. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | CANCERS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Genomic Signature of the Standardized Uptake Value in 18F-Fluorodeoxyglucose Positron Emission Tomography in Breast Cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학교실) | - |
dc.contributor.googleauthor | Seon-Kyu Kim | - |
dc.contributor.googleauthor | Sung Gwe Ahn | - |
dc.contributor.googleauthor | Jeong-Yeon Mun | - |
dc.contributor.googleauthor | Mi-So Jeong | - |
dc.contributor.googleauthor | Soong June Bae | - |
dc.contributor.googleauthor | Ju-Seog Lee | - |
dc.contributor.googleauthor | Joon Jeong | - |
dc.contributor.googleauthor | Sun-Hee Leem | - |
dc.contributor.googleauthor | In-Sun Chu | - |
dc.identifier.doi | 10.3390/cancers12020497 | - |
dc.contributor.localId | A05345 | - |
dc.contributor.localId | A02231 | - |
dc.contributor.localId | A03727 | - |
dc.relation.journalcode | J03449 | - |
dc.identifier.eissn | 2072-6694 | - |
dc.identifier.pmid | 32093417 | - |
dc.subject.keyword | FDG-PET | - |
dc.subject.keyword | Warburg effect | - |
dc.subject.keyword | breast cancer | - |
dc.subject.keyword | glucose metabolism | - |
dc.subject.keyword | immune checkpoint inhibitor | - |
dc.contributor.alternativeName | Bae, Soong June | - |
dc.contributor.affiliatedAuthor | 배숭준 | - |
dc.contributor.affiliatedAuthor | 안성귀 | - |
dc.contributor.affiliatedAuthor | 정준 | - |
dc.citation.volume | 12 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | E497 | - |
dc.identifier.bibliographicCitation | CANCERS, Vol.12(2) : E497, 2020 | - |
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