Cited 29 times in
Ternary nanocomposite carriers based on organic clay-lipid vesicles as an effective colon-targeted drug delivery system: preparation and in vitro/in vivo characterization
DC Field | Value | Language |
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dc.contributor.author | 천재희 | - |
dc.date.accessioned | 2020-04-13T16:53:59Z | - |
dc.date.available | 2020-04-13T16:53:59Z | - |
dc.date.issued | 2020 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/175557 | - |
dc.description.abstract | This study aimed to develop a new colon-targeted drug delivery system via the preparation of ternary nanocomposite carriers based on organic polymer, aminoclay and lipid vesicles. Budesonide (Bud), an anti-inflammatory drug was chosen as a model drug and encapsulated into three different formulations: liposome (Bud-Lip), aminoclay-coated liposome (AC-Bud-Lip), and Eudragit® S100-aminoclay double coated liposome (EAC-Bud-Lip). The formation of the aminoclay-lipid vesicle nanocomposite was confirmed by energy dispersive X-ray spectrum, transmission electron microscopy, and Fourier-transform infrared spectroscopy. All formulations were produced with a high encapsulation efficiency in a narrow size distribution. Drug release from EAC-Bud-Lip was approximately 10% for 2-h incubation at pH 1.2, implying the minimal drug release in acidic gastric condition. At pH 7.4, EAC-Bud-Lip underwent significant size reduction and exhibited drug release profiles similar to that from AC-Bud-Lip, implying the pH-dependent removal of the outer coating layer. Compared to free Bud solution, EAC-Bud-Lip achieved a higher drug uptake in Caco-2 cells and exhibited a stronger inhibition of TNF-α and IL-6 secretion in LPS-stimulated Raw264.7 cells. Furthermore, a bio-distribution study in mice demonstrated that Eudragit® S100-aminoclay dual coating led to a higher colonic distribution with a longer residence time, which correlated well with the delayed systemic drug exposure in rats. Taken together, the present study suggests that the ternary nanocomposite carrier consisting of Eudragit® S100, aminoclay, and lipid vesicle might be useful as an effective colon-targeted drug delivery system. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | BioMed Central | - |
dc.relation.isPartOf | JOURNAL OF NANOBIOTECHNOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Anti-Inflammatory Agents/chemistry* | - |
dc.subject.MESH | Anti-Inflammatory Agents/pharmacokinetics | - |
dc.subject.MESH | Budesonide/chemistry* | - |
dc.subject.MESH | Budesonide/pharmacokinetics | - |
dc.subject.MESH | Caco-2 Cells | - |
dc.subject.MESH | Clay/chemistry* | - |
dc.subject.MESH | Colon/metabolism* | - |
dc.subject.MESH | Drug Liberation | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hydrogen-Ion Concentration | - |
dc.subject.MESH | Interleukin-6/metabolism | - |
dc.subject.MESH | Lipids/chemistry* | - |
dc.subject.MESH | Liposomes/chemistry* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Nanocomposites/chemistry* | - |
dc.subject.MESH | Polymethacrylic Acids/chemistry | - |
dc.subject.MESH | RAW 264.7 Cells | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Solubility | - |
dc.subject.MESH | Surface Properties | - |
dc.subject.MESH | Tissue Distribution | - |
dc.subject.MESH | Tumor Necrosis Factor-alpha/metabolism | - |
dc.title | Ternary nanocomposite carriers based on organic clay-lipid vesicles as an effective colon-targeted drug delivery system: preparation and in vitro/in vivo characterization | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Hyeon Young Kim | - |
dc.contributor.googleauthor | Jae Hee Cheon | - |
dc.contributor.googleauthor | Sang Hoon Lee | - |
dc.contributor.googleauthor | Jeong Youn Min | - |
dc.contributor.googleauthor | Seung-Yun Back | - |
dc.contributor.googleauthor | Jae Geun Song | - |
dc.contributor.googleauthor | Da Hye Kim | - |
dc.contributor.googleauthor | Soo-Jeong Lim | - |
dc.contributor.googleauthor | Hyo-Kyung Han | - |
dc.identifier.doi | 10.1186/s12951-020-0579-7 | - |
dc.contributor.localId | A04030 | - |
dc.relation.journalcode | J03785 | - |
dc.identifier.eissn | 1477-3155 | - |
dc.identifier.pmid | 31964393 | - |
dc.subject.keyword | Aminoclay | - |
dc.subject.keyword | Colon-targeted | - |
dc.subject.keyword | Inflammatory disease | - |
dc.subject.keyword | Liposome | - |
dc.subject.keyword | Nanocomposite | - |
dc.subject.keyword | pH-dependent | - |
dc.contributor.alternativeName | Cheon, Jae Hee | - |
dc.contributor.affiliatedAuthor | 천재희 | - |
dc.citation.volume | 18 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 17 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NANOBIOTECHNOLOGY, Vol.18(1) : 17, 2020 | - |
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