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Quantitative Interpretation of Hydration Dynamics Enabled the Fabrication of a Zwitterionic Antifouling Surface

Authors
 Woojin Choi  ;  Jie Jin  ;  Sohyeon Park  ;  Ji-Yeong Kim  ;  Myung-Jin Lee  ;  Hyeongdeok Sun  ;  Jae-Sung Kwon  ;  Hwankyu Lee  ;  Sung-Hwan Choi  ;  Jinkee Hong 
Citation
 ACS APPLIED MATERIALS & INTERFACES, Vol.12(7) : 7951-7965, 2020 
Journal Title
 ACS APPLIED MATERIALS & INTERFACES 
ISSN
 1944-8244 
Issue Date
2020
Keywords
Raman spectroscopy ; antibacterial property ; antifouling property ; biomedical application ; grafting ; hydration ; mechanical strength ; medical device ; removable orthodontic retainer ; zwitterionic brush
Abstract
In the medical industry, zwitterionic brushes have received significant attention owing to their antifouling effect that arose from their hydration ability. However, sufficient understanding of the hydration dynamics of zwitterionic brushes is required to fabricate the precisely controlled antifouling medical devices. In this paper, we successfully show that hydration, the interaction between water molecules and zwitterionic brushes, and its dynamics can be evaluated logically and quantitatively using (i) water contact angle, (ii) molecular dynamics simulation, and (iii) Raman spectroscopy. Based on the intuitive results on hydration, we precisely optimized the antifouling property of the model medical device, a removable orthodontic retainer, with various grafting efficiencies of 2-methacryloyloxyethyl phosphate choline. As a result, the model device reduced nonspecific adsorption of proteins and bacteria, indicating an improved antifouling effect, and also inhibited the formation of a biofilm. Furthermore, the device showed excellent physical properties desirable for application in the orthodontic field, meaning the balance between the antibacterial property and mechanical strength.
Full Text
https://pubs.acs.org/doi/10.1021/acsami.9b21566
DOI
10.1021/acsami.9b21566
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Dental Biomaterials and Bioengineering (치과생체재료공학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Orthodontics (교정과학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Jae-Sung(권재성) ORCID logo https://orcid.org/0000-0001-9803-7730
Choi, Sung Hwan(최성환) ORCID logo https://orcid.org/0000-0002-1150-0268
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/175516
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