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Targeted therapy guided by single-cell transcriptomic analysis in drug-induced hypersensitivity syndrome: a case report
DC Field | Value | Language |
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dc.contributor.author | 김도영 | - |
dc.date.accessioned | 2020-04-13T16:47:16Z | - |
dc.date.available | 2020-04-13T16:47:16Z | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 1078-8956 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/175511 | - |
dc.description.abstract | Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms (DiHS/DRESS) is a potentially fatal multiorgan inflammatory disease associated with herpesvirus reactivation and subsequent onset of autoimmune diseases1-4. Pathophysiology remains elusive and therapeutic options are limited. Cases refractory to corticosteroid therapy pose a clinical challenge1,5 and approximately 30% of patients with DiHS/DRESS develop complications, including infections and inflammatory and autoimmune diseases1,2,5. Progress in single-cell RNA sequencing (scRNA-seq) provides an opportunity to dissect human disease pathophysiology at unprecedented resolutions6, particularly in diseases lacking animal models, such as DiHS/DRESS. We performed scRNA-seq on skin and blood from a patient with refractory DiHS/DRESS, identifying the JAK-STAT signaling pathway as a potential target. We further showed that central memory CD4+ T cells were enriched with DNA from human herpesvirus 6b. Intervention via tofacitinib enabled disease control and tapering of other immunosuppressive agents. Tofacitinib, as well as antiviral agents, suppressed culprit-induced T cell proliferation in vitro, further supporting the roles of the JAK-STAT pathway and herpesviruses in mediating the adverse drug reaction. Thus, scRNA-seq analyses guided successful therapeutic intervention in the patient with refractory DiHS/DRESS. scRNA-seq may improve our understanding of complicated human disease pathophysiology and provide an alternative approach in personalized medicine. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Nature Publishing Company | - |
dc.relation.isPartOf | NATURE MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Targeted therapy guided by single-cell transcriptomic analysis in drug-induced hypersensitivity syndrome: a case report | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Dermatology (피부과학교실) | - |
dc.contributor.googleauthor | Doyoung Kim | - |
dc.contributor.googleauthor | Tetsuro Kobayashi | - |
dc.contributor.googleauthor | Benjamin Voisin | - |
dc.contributor.googleauthor | Jay-Hyun Jo | - |
dc.contributor.googleauthor | Keiko Sakamoto | - |
dc.contributor.googleauthor | Seon-Pil Jin | - |
dc.contributor.googleauthor | Michael Kelly | - |
dc.contributor.googleauthor | Helena B. Pasieka | - |
dc.contributor.googleauthor | Jessica L. Naff | - |
dc.contributor.googleauthor | Jon H. Meyerle | - |
dc.contributor.googleauthor | Ijeoma D. Ikpeama | - |
dc.contributor.googleauthor | Gary A. Fahle | - |
dc.contributor.googleauthor | Fred P. Davis | - |
dc.contributor.googleauthor | Sergio D. Rosenzweig | - |
dc.contributor.googleauthor | Julie C. Alejo | - |
dc.contributor.googleauthor | Stefania Pittaluga | - |
dc.contributor.googleauthor | Heidi H. Kong | - |
dc.contributor.googleauthor | Alexandra F. Freeman | - |
dc.contributor.googleauthor | Keisuke Nagao | - |
dc.identifier.doi | 10.1038/s41591-019-0733-7 | - |
dc.contributor.localId | A00384 | - |
dc.relation.journalcode | J02296 | - |
dc.identifier.eissn | 1546-170X | - |
dc.identifier.pmid | 31959990 | - |
dc.identifier.url | https://www.nature.com/articles/s41591-019-0733-7 | - |
dc.contributor.alternativeName | Kim, Do Young | - |
dc.contributor.affiliatedAuthor | 김도영 | - |
dc.citation.volume | 26 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 236 | - |
dc.citation.endPage | 243 | - |
dc.identifier.bibliographicCitation | NATURE MEDICINE, Vol.26(2) : 236-243, 2020 | - |
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