Cited 15 times in
Comparison of First-Line Dual Combination Treatments in Hypertension: Real-World Evidence from Multinational Heterogeneous Cohorts
DC Field | Value | Language |
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dc.contributor.author | 박성하 | - |
dc.date.accessioned | 2020-02-26T06:48:27Z | - |
dc.date.available | 2020-02-26T06:48:27Z | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 1738-5520 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/175295 | - |
dc.description.abstract | BACKGROUND AND OBJECTIVES: 2018 ESC/ESH Hypertension guideline recommends 2-drug combination as initial anti-hypertensive therapy. However, real-world evidence for effectiveness of recommended regimens remains limited. We aimed to compare the effectiveness of first-line anti-hypertensive treatment combining 2 out of the following classes: angiotensin-converting enzyme (ACE) inhibitors/angiotensin-receptor blocker (A), calcium channel blocker (C), and thiazide-type diuretics (D). METHODS: Treatment-naïve hypertensive adults without cardiovascular disease (CVD) who initiated dual anti-hypertensive medications were identified in 5 databases from US and Korea. The patients were matched for each comparison set by large-scale propensity score matching. Primary endpoint was all-cause mortality. Myocardial infarction, heart failure, stroke, and major adverse cardiac and cerebrovascular events as a composite outcome comprised the secondary measure. RESULTS: A total of 987,983 patients met the eligibility criteria. After matching, 222,686, 32,344, and 38,513 patients were allocated to A+C vs. A+D, C+D vs. A+C, and C+D vs. A+D comparison, respectively. There was no significant difference in the mortality during total of 1,806,077 person-years: A+C vs. A+D (hazard ratio [HR], 1.08; 95% confidence interval [CI], 0.97-1.20; p=0.127), C+D vs. A+C (HR, 0.93; 95% CI, 0.87-1.01; p=0.067), and C+D vs. A+D (HR, 1.18; 95% CI, 0.95-1.47; p=0.104). A+C was associated with a slightly higher risk of heart failure (HR, 1.09; 95% CI, 1.01-1.18; p=0.040) and stroke (HR, 1.08; 95% CI, 1.01-1.17; p=0.040) than A+D. CONCLUSIONS: There was no significant difference in mortality among A+C, A+D, and C+D combination treatment in patients without previous CVD. This finding was consistent across multi-national heterogeneous cohorts in real-world practice. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English, Korean | - |
dc.publisher | Korean Society of Circulation | - |
dc.relation.isPartOf | KOREAN CIRCULATION JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Comparison of First-Line Dual Combination Treatments in Hypertension: Real-World Evidence from Multinational Heterogeneous Cohorts | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Seng Chan You | - |
dc.contributor.googleauthor | Sungjae Jung | - |
dc.contributor.googleauthor | Joel N. Swerdel | - |
dc.contributor.googleauthor | Patrick B. Ryan | - |
dc.contributor.googleauthor | Martijn J. Schuemie | - |
dc.contributor.googleauthor | Marc A. Suchard | - |
dc.contributor.googleauthor | Seongwon Lee | - |
dc.contributor.googleauthor | Jaehyeong Cho | - |
dc.contributor.googleauthor | George Hripcsak | - |
dc.contributor.googleauthor | Rae Woong Park | - |
dc.contributor.googleauthor | Sungha Park | - |
dc.identifier.doi | 10.4070/kcj.2019.0173 | - |
dc.contributor.localId | A01512 | - |
dc.relation.journalcode | J01952 | - |
dc.identifier.eissn | 1738-5555 | - |
dc.identifier.pmid | 31642211 | - |
dc.subject.keyword | Angiotensin receptor antagonists | - |
dc.subject.keyword | Antihypertensive agents | - |
dc.subject.keyword | Calcium channel blockers | - |
dc.subject.keyword | Diuretics | - |
dc.subject.keyword | Hypertension | - |
dc.contributor.alternativeName | Park, Sung Ha | - |
dc.contributor.affiliatedAuthor | 박성하 | - |
dc.citation.volume | 50 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 52 | - |
dc.citation.endPage | 68 | - |
dc.identifier.bibliographicCitation | KOREAN CIRCULATION JOURNAL, Vol.50(1) : 52-68, 2020 | - |
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