Cited 11 times in
Is hepatectomy safe following Yttrium-90 therapy? A multi-institutional international experience
DC Field | Value | Language |
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dc.contributor.author | 최기홍 | - |
dc.date.accessioned | 2020-02-26T06:36:16Z | - |
dc.date.available | 2020-02-26T06:36:16Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 1365-182X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/175216 | - |
dc.description.abstract | BACKGROUND: Single institution reports demonstrate variable safety profiles when liver-directed therapy with Yttrium-90 (Y-90) is followed by hepatectomy. We hypothesized that in well-selected patients, hepatectomy after Y90 is feasible and safe. METHODS: Nine institutions contributed data for patients undergoing Y90 followed by hepatectomy (2008-2017). Clinicopathologic and perioperative data were analyzed, with 90-day morbidity and mortality as primary endpoints. RESULTS: Forty-seven patients were included. Median age was 59 (20-75) and 62% were male. Malignancies treated included hepatocellular cancer (n = 14; 30%), colorectal cancer (n = 11; 23%), cholangiocarcinoma (n = 8; 17%), neuroendocrine (n = 8; 17%) and other tumors (n = 6). The distribution of Y-90 treatment was: right (n = 30; 64%), bilobar (n = 14; 30%), and left (n = 3; 6%). Median future liver remnant (FLR) following Y90 was 44% (30-78). Resections were primarily right (n = 16; 34%) and extended right (n = 14; 30%) hepatectomies. The median time to resection from Y90 was 196 days (13-947). The 90-day complication rate was 43% and mortality was 2%. Risk factors for Clavien-Dindo Grade>3 complications included: number of Y-90-treated lobes (OR 4.5; 95% CI1.14-17.7; p = 0.03), extent of surgery (p = 0.04) and operative time (p = 0.009). CONCLUSIONS: These data demonstrate that hepatectomy following Y-90 is safe in well-selected populations. This multi-disciplinary treatment paradigm should be more widely studied, and potentially adopted, for patients with inadequate FLR. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | HPB | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Is hepatectomy safe following Yttrium-90 therapy? A multi-institutional international experience | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학교실) | - |
dc.contributor.googleauthor | Laleh G. Melstrom | - |
dc.contributor.googleauthor | Oliver S. Eng | - |
dc.contributor.googleauthor | Mustafa Raoof | - |
dc.contributor.googleauthor | Gagandeep Singh | - |
dc.contributor.googleauthor | Yuman Fong | - |
dc.contributor.googleauthor | Karen Latorre | - |
dc.contributor.googleauthor | Gi H. Choi | - |
dc.contributor.googleauthor | Riad Salem | - |
dc.contributor.googleauthor | David J. Bentrem | - |
dc.contributor.googleauthor | Robert Lewandowski | - |
dc.contributor.googleauthor | Eleftherios Makris | - |
dc.contributor.googleauthor | George Poultsides | - |
dc.contributor.googleauthor | Vikrom K. Dhar | - |
dc.contributor.googleauthor | Seetharam hadalavada | - |
dc.contributor.googleauthor | Shimul A. Shah | - |
dc.contributor.googleauthor | Aileen C. Johnson | - |
dc.contributor.googleauthor | Aarti Sekhar | - |
dc.contributor.googleauthor | Darren Kies | - |
dc.contributor.googleauthor | Shishir K. Maithel | - |
dc.contributor.googleauthor | Flavio Rocha | - |
dc.contributor.googleauthor | Adnan Alseidi | - |
dc.contributor.googleauthor | Jeroen Hagendoorn | - |
dc.contributor.googleauthor | Inne H.M. Borel Rinkes | - |
dc.contributor.googleauthor | Alexander V. Fisher | - |
dc.contributor.googleauthor | Sean Ronnekleiv-Kelly | - |
dc.contributor.googleauthor | Sharon M. Weber | - |
dc.contributor.googleauthor | Emily R. Winslow | - |
dc.contributor.googleauthor | Daniel E. Abbott | - |
dc.identifier.doi | 10.1016/j.hpb.2019.03.366 | - |
dc.contributor.localId | A04046 | - |
dc.relation.journalcode | J03345 | - |
dc.identifier.eissn | 1477-2574 | - |
dc.identifier.pmid | 31005493 | - |
dc.identifier.url | https://www.clinicalkey.com/#!/content/playContent/1-s2.0-S1365182X19304915 | - |
dc.contributor.alternativeName | Choi, Gi Hong | - |
dc.contributor.affiliatedAuthor | 최기홍 | - |
dc.citation.volume | 21 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 1520 | - |
dc.citation.endPage | 1526 | - |
dc.identifier.bibliographicCitation | HPB, Vol.21(11) : 1520-1526, 2019 | - |
dc.identifier.rimsid | 63606 | - |
dc.type.rims | ART | - |
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