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Human Neural Stem Cells: Translational Research for Neonatal Hypoxic-Ischemic Brain Injury

DC Field Value Language
dc.contributor.author박국인-
dc.contributor.author신정은-
dc.contributor.author은호선-
dc.contributor.author임주희-
dc.contributor.author한정호-
dc.date.accessioned2020-02-26T06:30:50Z-
dc.date.available2020-02-26T06:30:50Z-
dc.date.issued2019-
dc.identifier.issn2287-9412-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/175182-
dc.description.abstractNeonatal hypoxic-ischemic (HI) brain injury is a major cause of neonatal mortality and long-term neurodevelopmental disabilities. Although promising neuroprotective interventions have been studied, the current management of HI brain injury has been limited to supportive measures and induced hypothermia. In addition to engrafting, migrating toward the damage sites and differentiating into multiple lineages, multipotent neural stem/progenitor cells (NSPCs) also provide trophic/immunomodulatory factors and integrate into the host neurons upon implantation into an HI-injured brain. However, NSPC-based therapies have shown poor cell survival and integration, poor differentiation or restricted differentiation into the glial lineages. Furthermore, to achieve full functional recovery following brain injury, the optimization of cell therapy is needed to recapitulate the precise migration of stem cells to the region of interest and the neural rewiring present in the brain microenvironment. Therefore, the efficacy of NSPCs in the treatment of CNS injury is currently insufficient. Human NSPCs (hNSPCs) were isolated from the forebrain of an aborted fetus at 13 weeks of gestation with full parental consent and the approval of the Institutional Review Board of the Yonsei University College of Medicine. Here, to enhance the regenerative ability of hNSPCs in HI brain injury, cells were either pretreated with pharmacological agents or engineered to serve as vehicles for gene delivery. Furthermore, when combined with a poly (glycolic acid)-based synthetic scaffold, hNSPCs provide a more versatile treatment for neonatal HI brain injury. Finally, hNSPCs transfected with zinc-doped ferrite magnetic nanoparticles for controlling both cell migration and differentiation offer a simple and smart tool for cell-based therapies.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageKorean-
dc.publisherKorean Society of Neonatology-
dc.relation.isPartOfNeonatal Medicine-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleHuman Neural Stem Cells: Translational Research for Neonatal Hypoxic-Ischemic Brain Injury-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pediatrics (소아청소년과학교실)-
dc.contributor.googleauthorJeong Eun Shin-
dc.contributor.googleauthorJungho Han-
dc.contributor.googleauthorJoo Hee Lim-
dc.contributor.googleauthorHo Seon Eun-
dc.contributor.googleauthorKook In Park-
dc.identifier.doi10.5385/nm.2019.26.1.1-
dc.identifier.doi10.5385/nm.2019.26.1.1-
dc.contributor.localIdA01438-
dc.contributor.localIdA02152-
dc.contributor.localIdA02635-
dc.contributor.localIdA05023-
dc.contributor.localIdA05064-
dc.relation.journalcodeJ02310-
dc.identifier.eissn2287-9803-
dc.subject.keywordNeural stem cells-
dc.subject.keywordHypoxia-ischemia-
dc.subject.keywordbrain-
dc.subject.keywordCell therapy-
dc.subject.keywordGenetic therapy-
dc.contributor.alternativeNamePark, Kook In-
dc.contributor.affiliatedAuthor박국인-
dc.contributor.affiliatedAuthor신정은-
dc.contributor.affiliatedAuthor은호선-
dc.contributor.affiliatedAuthor임주희-
dc.contributor.affiliatedAuthor한정호-
dc.citation.volume26-
dc.citation.number1-
dc.citation.startPage1-
dc.citation.endPage16-
dc.identifier.bibliographicCitationNeonatal Medicine, Vol.26(1) : 1-16, 2019-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers

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