Cited 232 times in
A Variant of SLC1A5 Is a Mitochondrial Glutamine Transporter for Metabolic Reprogramming in Cancer Cells
DC Field | Value | Language |
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dc.contributor.author | 방승민 | - |
dc.date.accessioned | 2020-02-26T06:29:28Z | - |
dc.date.available | 2020-02-26T06:29:28Z | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 1550-4131 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/175172 | - |
dc.description.abstract | Glutamine is an essential nutrient that regulates energy production, redox homeostasis, and signaling in cancer cells. Despite the importance of glutamine in mitochondrial metabolism, the mitochondrial glutamine transporter has long been unknown. Here, we show that the SLC1A5 variant plays a critical role in cancer metabolic reprogramming by transporting glutamine into mitochondria. The SLC1A5 variant has an N-terminal targeting signal for mitochondrial localization. Hypoxia-induced gene expression of the SLC1A5 variant is mediated by HIF-2α. Overexpression of the SLC1A5 variant mediates glutamine-induced ATP production and glutathione synthesis and confers gemcitabine resistance to pancreatic cancer cells. SLC1A5 variant knockdown and overexpression alter cancer cell and tumor growth, supporting an oncogenic role. This work demonstrates that the SLC1A5 variant is a mitochondrial glutamine transporter for cancer metabolic reprogramming. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Cell Press | - |
dc.relation.isPartOf | CELL METABOLISM | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | A Variant of SLC1A5 Is a Mitochondrial Glutamine Transporter for Metabolic Reprogramming in Cancer Cells | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Hee Chan Yoo | - |
dc.contributor.googleauthor | Seung Joon Park | - |
dc.contributor.googleauthor | Miso Nam | - |
dc.contributor.googleauthor | Juwon Kang | - |
dc.contributor.googleauthor | Kibum Kim | - |
dc.contributor.googleauthor | Joo Hye Yeo | - |
dc.contributor.googleauthor | Joon-Ki Kim | - |
dc.contributor.googleauthor | Yunkyung Heo | - |
dc.contributor.googleauthor | Hee Seung Lee | - |
dc.contributor.googleauthor | Myeong Youl Lee | - |
dc.contributor.googleauthor | Chang Woo Lee | - |
dc.contributor.googleauthor | Jong Soon Kang | - |
dc.contributor.googleauthor | Yun-Hee Kim | - |
dc.contributor.googleauthor | Jinu Lee | - |
dc.contributor.googleauthor | Junjeong Choi | - |
dc.contributor.googleauthor | Geum-Sook Hwang | - |
dc.contributor.googleauthor | Seungmin Bang | - |
dc.contributor.googleauthor | Jung Min Han | - |
dc.identifier.doi | 10.1016/j.cmet.2019.11.020 | - |
dc.contributor.localId | A01786 | - |
dc.relation.journalcode | J00486 | - |
dc.identifier.eissn | 1932-7420 | - |
dc.identifier.pmid | 31866442 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S1550413119306643 | - |
dc.subject.keyword | ASCT2 | - |
dc.subject.keyword | HIF-2α | - |
dc.subject.keyword | SLC1A5 | - |
dc.subject.keyword | SLC1A5 variant | - |
dc.subject.keyword | cancer metabolism | - |
dc.subject.keyword | gemcitabine resistance | - |
dc.subject.keyword | glutamine | - |
dc.subject.keyword | hypoxia | - |
dc.subject.keyword | metabolic reprogramming | - |
dc.subject.keyword | mitochondrial glutamine transporter | - |
dc.contributor.alternativeName | Bang, Seungmin | - |
dc.contributor.affiliatedAuthor | 방승민 | - |
dc.citation.volume | 31 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 267 | - |
dc.citation.endPage | 283.e12 | - |
dc.identifier.bibliographicCitation | CELL METABOLISM, Vol.31(2) : 267-283.e12, 2020 | - |
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