Long Noncoding RNA Steroid Receptor Activator Induces Tumor Proliferation and Invasion through the Notch Pathway in Cervical Cancer Cell Lines

Abstract

Background: Recent research has focused on the impact of long noncoding RNA (lncRNA) in cervical carcinogenesis. However, whether steroid receptor activator (SRA) lncRNA is involved in cervical cancer remains to be elucidated. Materials and Methods: We investigated the bio-functional consequences of SRA knockdown in vitro. To determine the role of SRA in cell proliferation, migration, and invasion, RNA interference was used to knockdown SRA expression in cervical cancer cells. Results: We found SRA knockdown inhibited cell proliferation, migration, and tumor invasion. In vitro experiments using the SRA-knockdown CaSki and SiHa cell line revealed that SRA was a strong inducer of tumor growth and a modulator of the expression of epithelial mesenchymal transition and Notch signaling pathway-related genes. Conclusion: Our results suggested that SRA is associated with invasiveness and biological aggressiveness in cervical cancer cells. Thus, SRA may be a potential therapeutic target and biological marker for cervical cancer.