Cited 52 times in
High-protein diet with renal hyperfiltration is associated with rapid decline rate of renal function: a community-based prospective cohort study
DC Field | Value | Language |
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dc.contributor.author | 강신욱 | - |
dc.contributor.author | 박서현 | - |
dc.contributor.author | 박정탁 | - |
dc.contributor.author | 유태현 | - |
dc.contributor.author | 지종현 | - |
dc.contributor.author | 한승혁 | - |
dc.date.accessioned | 2020-02-11T06:57:36Z | - |
dc.date.available | 2020-02-11T06:57:36Z | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 0931-0509 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/174919 | - |
dc.description.abstract | BACKGROUND: The effect of a high-protein diet with renal hyperfiltration (RHF) on decline of kidney function has rarely been explored. We investigated the association between a high-protein diet, RHF and declining kidney function. METHODS: A total of 9226 subjects from the Korean Genome and Epidemiology Study, a community-based prospective study (2001-14), were enrolled and classified into quartiles according to daily amount of protein intake based on food frequency questionnaires. RHF was defined as estimated glomerular filtration rate (eGFR) with residuals of >95th percentile after adjustment for age, sex, history of hypertension or diabetes, height and weight. Rapid decline of renal function was defined as decline rate of eGFR >3 mL/min/1.73 m2/year. RESULTS: The relative risk of RHF was 3.48-fold higher in the highest than in the lowest protein intake quartile after adjustment for confounding factors [95% confidence interval (CI) 1.39-8.71]. The mean eGFR decline rate was faster as quartiles of protein intake increased. Furthermore, the highest quartile was associated with 1.32-fold increased risk of rapid eGFR decline (95% CI 1.02-1.73). When subjects were divided into two groups with or without RHF, the highest quartile was associated with a rapid decline in renal function only in RHF subjects (odds ratio 3.35; 95% CI 1.07-10.51). The sensitivity analysis using the Korean National Health and Nutrition Examination Survey (2008-15) data with 40 113 subjects showed that higher quartile was associated with increased risk for RHF. CONCLUSIONS: A high-protein diet increases the risk of RHF and a rapid renal function decline in the general population. These findings suggest that a high-protein diet has a deleterious effect on renal function in the general population. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Oxford University Press | - |
dc.relation.isPartOf | Nephrology Dialysis Transplantation | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | High-protein diet with renal hyperfiltration is associated with rapid decline rate of renal function: a community-based prospective cohort study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Jong Hyun Jhee | - |
dc.contributor.googleauthor | Youn Kyung Kee | - |
dc.contributor.googleauthor | Seohyun Park | - |
dc.contributor.googleauthor | Hyoungnae Kim | - |
dc.contributor.googleauthor | Jung Tak Park | - |
dc.contributor.googleauthor | Seung Hyeok Han | - |
dc.contributor.googleauthor | Shin-Wook Kang | - |
dc.contributor.googleauthor | Tae-Hyun Yoo | - |
dc.identifier.doi | 10.1093/ndt/gfz115 | - |
dc.contributor.localId | A00053 | - |
dc.contributor.localId | A01495 | - |
dc.contributor.localId | A01654 | - |
dc.contributor.localId | A02526 | - |
dc.contributor.localId | A03970 | - |
dc.contributor.localId | A04304 | - |
dc.relation.journalcode | J02316 | - |
dc.identifier.eissn | 1460-2385 | - |
dc.identifier.pmid | 31172186 | - |
dc.identifier.url | https://academic.oup.com/ndt/article/35/1/98/5511599 | - |
dc.subject.keyword | estimated glomerular filtration rate | - |
dc.subject.keyword | kidney function | - |
dc.subject.keyword | protein intake | - |
dc.subject.keyword | rapid decline | - |
dc.subject.keyword | renal hyperfiltration | - |
dc.contributor.alternativeName | Kang, Shin Wook | - |
dc.contributor.affiliatedAuthor | 강신욱 | - |
dc.contributor.affiliatedAuthor | 박서현 | - |
dc.contributor.affiliatedAuthor | 박정탁 | - |
dc.contributor.affiliatedAuthor | 유태현 | - |
dc.contributor.affiliatedAuthor | 지종현 | - |
dc.contributor.affiliatedAuthor | 한승혁 | - |
dc.citation.volume | 35 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 98 | - |
dc.citation.endPage | 106 | - |
dc.identifier.bibliographicCitation | Nephrology Dialysis Transplantation, Vol.35(1) : 98-106, 2020 | - |
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