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Glioblastoma Cellular Origin and the Firework Pattern of Cancer Genesis from the Subventricular Zone

Authors
 Seon-Jin Yoon  ;  Junseong Park  ;  Dong-Su Jang  ;  Hyun Jung Kim  ;  Joo Ho Lee  ;  Euna Jo  ;  Ran Joo Choi  ;  Jin-Kyung Shim  ;  Ju Hyung Moon  ;  Eui-Hyun Kim  ;  Jong Hee Chang  ;  Jeong Ho Lee  ;  Seok-Gu Kang 
Citation
 JOURNAL OF KOREAN NEUROSURGICAL SOCIETY, Vol.63(1) : 26-33, 2020 
Journal Title
 JOURNAL OF KOREAN NEUROSURGICAL SOCIETY 
ISSN
 2005-3711 
Issue Date
2020
Keywords
Cancer genesis ; Cell-of-origin ; Clock-like mutation ; Firework pattern ; Glioblastoma ; Subventricular zone
Abstract
Glioblastoma (GBM) is a disease without any definite cure. Numerous approaches have been tested in efforts to conquer this brain disease, but patients invariably experience recurrence or develop resistance to treatment. New surgical tools, carefully chosen samples, and experimental methods are enabling discoveries at single-cell resolution. The present article reviews the cell-of-origin of isocitrate dehydrogenase (IDH)-wildtype GBM, beginning with the historical background for focusing on cellular origin and introducing the cancer genesis patterned on firework. The authors also review mutations associated with the senescence process in cells of the subventricular zone (SVZ), and biological validation of somatic mutations in a mouse SVZ model. Understanding GBM would facilitate research on the origin of other cancers and may catalyze the development of new management approaches or treatments against IDH-wildtype GBM.
Files in This Item:
T202000120.pdf Download
DOI
10.3340/jkns.2019.0129
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
Yonsei Authors
Kang, Seok Gu(강석구) ORCID logo https://orcid.org/0000-0001-5676-2037
Kim, Eui Hyun(김의현) ORCID logo https://orcid.org/0000-0002-2523-7122
Moon, Ju Hyung(문주형)
Park, Junseong(박준성)
Yoon, Seon Jin(윤선진) ORCID logo https://orcid.org/0000-0002-3255-5081
Chang, Jong Hee(장종희) ORCID logo https://orcid.org/0000-0003-1509-9800
Choi, Ran Joo(최란주)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/174900
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