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Association of opioid receptor gene polymorphisms with drinking severity and impulsivity related to alcohol use disorder in a Korean population

DC Field Value Language
dc.contributor.author강지인-
dc.contributor.author김세주-
dc.contributor.author김혜원-
dc.contributor.author박천일-
dc.contributor.author이상학-
dc.date.accessioned2020-02-11T06:54:28Z-
dc.date.available2020-02-11T06:54:28Z-
dc.date.issued2020-
dc.identifier.issn1755-5930-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/174895-
dc.description.abstractAIMS: Recent evidence suggests that the opioid system is implicated in the pathophysiology of alcohol use disorder (AUD). We aimed to examine the genetic influence of opioid receptors on susceptibility to AUD and its clinical and psychological characteristics including harmful drinking behavior and various aspects of impulsivity in AUD patients. METHODS: Three μ-opioid receptor gene (OPRM1) variants and two κ-opioid receptor gene (OPRK1) variants were examined in 314 male patients with AUD and 324 male controls. We applied the Alcohol Use Disorders Identification Test (AUDIT), Obsessive Compulsive Drinking Scale (OCDS), and Alcohol Dependence Scale. AUD patients also completed the stop-signal task, delay discounting task, balloon analogue risk task, and the Barratt Impulsiveness Scale version 11 (BIS-11). RESULTS: No significant differences in genotype distributions or haplotype frequencies were found between AUD patients and controls. However, OPRK1 SNP rs6473797 was significantly related to the severity of alcohol-related symptoms as measured by AUDIT and OCDS and a haplotype containing rs6473797 was also related to OCDS scores in AUD patients. For other psychological traits, OPRM1 SNP rs495491 was significantly associated with scores on the motor subfactor of the BIS-11. CONCLUSION: Genetic variations in opioid receptors may contribute to symptom severity and impulsivity in AUD patients.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherWiley-Blackwell-
dc.relation.isPartOfCNS NEUROSCIENCE & THERAPEUTICS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleAssociation of opioid receptor gene polymorphisms with drinking severity and impulsivity related to alcohol use disorder in a Korean population-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Psychiatry (정신과학교실)-
dc.contributor.googleauthorChun Il Park-
dc.contributor.googleauthorSyung Shick Hwang-
dc.contributor.googleauthorHae Won Kim-
dc.contributor.googleauthorJee In Kang-
dc.contributor.googleauthorSang Hak Lee-
dc.contributor.googleauthorSe Joo Kim-
dc.identifier.doi10.1111/cns.13138-
dc.contributor.localIdA00084-
dc.contributor.localIdA00604-
dc.contributor.localIdA04920-
dc.contributor.localIdA05693-
dc.contributor.localIdA02833-
dc.relation.journalcodeJ03071-
dc.identifier.eissn1755-5949-
dc.identifier.pmid31004399-
dc.subject.keywordalcohol use disorder-
dc.subject.keyworddrinking severity-
dc.subject.keywordimpulsivity-
dc.subject.keywordopioid receptor gene-
dc.contributor.alternativeNameKang, Jee In-
dc.contributor.affiliatedAuthor강지인-
dc.contributor.affiliatedAuthor김세주-
dc.contributor.affiliatedAuthor김혜원-
dc.contributor.affiliatedAuthor박천일-
dc.contributor.affiliatedAuthor이상학-
dc.citation.volume26-
dc.citation.number1-
dc.citation.startPage30-
dc.citation.endPage38-
dc.identifier.bibliographicCitationCNS NEUROSCIENCE & THERAPEUTICS, Vol.26(1) : 30-38, 2020-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Medical Education (의학교육학과) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers

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