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Increased frequency of CD4+CD57+ senescent T cells in patients with newly diagnosed acute heart failure: exploring new pathogenic mechanisms with clinical relevance
DC Field | Value | Language |
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dc.contributor.author | 강석민 | - |
dc.contributor.author | 유희태 | - |
dc.date.accessioned | 2020-02-11T06:44:31Z | - |
dc.date.available | 2020-02-11T06:44:31Z | - |
dc.date.issued | 2019 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/174824 | - |
dc.description.abstract | Recent animal studies showed T cells have a direct pathogenic role in the development of heart failure (HF). However, which subsets of T cells contribute to human HF pathogenesis and progression remains unclear. We characterized immunologic properties of various subsets of T cells and their clinical implications in human HF. Thirty-eight consecutive patients with newly diagnosed acute HF (21 males, mean age 66 ± 16 years) and 38 healthy control subjects (21 males, mean age 62 ± 12 years) were enrolled. We found that pro-inflammatory mediators, including CRP, IL-6 and IP-10 and the frequencies of CD57+ T cells in the CD4+ T cell population were significantly elevated in patients with acute HF compared to control subjects. A functional analysis of T cells from patients with acute HF revealed that the CD4+CD57+ T cell population exhibited a higher frequency of IFN-γ- and TNF-α- producing cells compared to the CD4+CD57- T cell population. Furthermore, the frequency of CD4+CD57+ T cells at baseline and its elevation at the six-month follow-up were significantly related with the development of cardiovascular (CV) events, which were defined as CV mortality, cardiac transplantation, or rehospitalization due to HF exacerbation. In conclusion, CD4+CD57+ senescent T cells showed more inflammatory features and polyfunctionality and were associated with clinical outcome in patients with acute HF. More detailed study for senescent T cells might offer new opportunities for the prevention and treatment of human HF. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Increased frequency of CD4+CD57+ senescent T cells in patients with newly diagnosed acute heart failure: exploring new pathogenic mechanisms with clinical relevance | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Jong-Chan Youn | - |
dc.contributor.googleauthor | Min Kyung Jung | - |
dc.contributor.googleauthor | Hee Tae Yu | - |
dc.contributor.googleauthor | Ji-Soo Kwon | - |
dc.contributor.googleauthor | Jeong-Eun Kwak | - |
dc.contributor.googleauthor | Su-Hyung Park | - |
dc.contributor.googleauthor | In-Cheol Kim | - |
dc.contributor.googleauthor | Myung-Soo Park | - |
dc.contributor.googleauthor | Sun Ki Lee | - |
dc.contributor.googleauthor | Suk-Won Choi | - |
dc.contributor.googleauthor | Seongwoo Han | - |
dc.contributor.googleauthor | Kyu-Hyung Ryu | - |
dc.contributor.googleauthor | Seok-Min Kang | - |
dc.contributor.googleauthor | Eui-Cheol Shin | - |
dc.identifier.doi | 10.1038/s41598-019-49332-5 | - |
dc.contributor.localId | A00037 | - |
dc.contributor.localId | A02535 | - |
dc.relation.journalcode | J02646 | - |
dc.identifier.eissn | 2045-2322 | - |
dc.identifier.pmid | 31501486 | - |
dc.contributor.alternativeName | Kang, Seok Min | - |
dc.contributor.affiliatedAuthor | 강석민 | - |
dc.contributor.affiliatedAuthor | 유희태 | - |
dc.citation.volume | 9 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 12887 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, Vol.9(1) : 12887, 2019 | - |
dc.identifier.rimsid | 63249 | - |
dc.type.rims | ART | - |
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