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Increased frequency of CD4+CD57+ senescent T cells in patients with newly diagnosed acute heart failure: exploring new pathogenic mechanisms with clinical relevance

DC FieldValueLanguage
dc.contributor.author강석민-
dc.contributor.author유희태-
dc.date.accessioned2020-02-11T06:44:31Z-
dc.date.available2020-02-11T06:44:31Z-
dc.date.issued2019-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/174824-
dc.description.abstractRecent animal studies showed T cells have a direct pathogenic role in the development of heart failure (HF). However, which subsets of T cells contribute to human HF pathogenesis and progression remains unclear. We characterized immunologic properties of various subsets of T cells and their clinical implications in human HF. Thirty-eight consecutive patients with newly diagnosed acute HF (21 males, mean age 66 ± 16 years) and 38 healthy control subjects (21 males, mean age 62 ± 12 years) were enrolled. We found that pro-inflammatory mediators, including CRP, IL-6 and IP-10 and the frequencies of CD57+ T cells in the CD4+ T cell population were significantly elevated in patients with acute HF compared to control subjects. A functional analysis of T cells from patients with acute HF revealed that the CD4+CD57+ T cell population exhibited a higher frequency of IFN-γ- and TNF-α- producing cells compared to the CD4+CD57- T cell population. Furthermore, the frequency of CD4+CD57+ T cells at baseline and its elevation at the six-month follow-up were significantly related with the development of cardiovascular (CV) events, which were defined as CV mortality, cardiac transplantation, or rehospitalization due to HF exacerbation. In conclusion, CD4+CD57+ senescent T cells showed more inflammatory features and polyfunctionality and were associated with clinical outcome in patients with acute HF. More detailed study for senescent T cells might offer new opportunities for the prevention and treatment of human HF.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherNature Publishing Group-
dc.relation.isPartOfSCIENTIFIC REPORTS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleIncreased frequency of CD4+CD57+ senescent T cells in patients with newly diagnosed acute heart failure: exploring new pathogenic mechanisms with clinical relevance-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorJong-Chan Youn-
dc.contributor.googleauthorMin Kyung Jung-
dc.contributor.googleauthorHee Tae Yu-
dc.contributor.googleauthorJi-Soo Kwon-
dc.contributor.googleauthorJeong-Eun Kwak-
dc.contributor.googleauthorSu-Hyung Park-
dc.contributor.googleauthorIn-Cheol Kim-
dc.contributor.googleauthorMyung-Soo Park-
dc.contributor.googleauthorSun Ki Lee-
dc.contributor.googleauthorSuk-Won Choi-
dc.contributor.googleauthorSeongwoo Han-
dc.contributor.googleauthorKyu-Hyung Ryu-
dc.contributor.googleauthorSeok-Min Kang-
dc.contributor.googleauthorEui-Cheol Shin-
dc.identifier.doi10.1038/s41598-019-49332-5-
dc.contributor.localIdA00037-
dc.contributor.localIdA02535-
dc.contributor.localIdA02535-
dc.relation.journalcodeJ02646-
dc.identifier.eissn2045-2322-
dc.identifier.pmid31501486-
dc.contributor.alternativeNameKang, Seok Min-
dc.contributor.affiliatedAuthor강석민-
dc.contributor.affiliatedAuthor유희태-
dc.contributor.affiliatedAuthor유희태-
dc.citation.volume9-
dc.citation.number1-
dc.citation.startPage12887-
dc.identifier.bibliographicCitationSCIENTIFIC REPORTS, Vol.9(1) : 12887, 2019-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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