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High CD3 and ICOS and low TIM-3 expression predict favourable survival in resected oesophageal squamous cell carcinoma

DC FieldValueLanguage
dc.contributor.author김대준-
dc.contributor.author김혜련-
dc.contributor.author박성용-
dc.contributor.author신성관-
dc.contributor.author신수진-
dc.contributor.author조병철-
dc.contributor.author홍민희-
dc.date.accessioned2020-02-11T06:42:59Z-
dc.date.available2020-02-11T06:42:59Z-
dc.date.issued2019-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/174801-
dc.description.abstractWith the increasing oncological potential of immunotherapy, several immune checkpoint modulators are being investigated. The value of immune markers, including programmed cell death ligand-1, programmed cell death-1 (PD-1), inducible co-stimulator (ICOS), lymphocyte activation gene-3, T-cell immunoglobulin, and mucin-dominant containing-3 (TIM-3), is not well known. Using tissue microarrays of 396 patients who underwent surgery for oesophageal squamous cell carcinoma (ESCC), infiltrated T-cell subsets (CD3, CD8, and Foxp3) and checkpoint protein expression were scored. With a median follow-up of 24.8 months, CD3+ TIL subsets (50.0%) had longer median recurrence-free survival (RFS, 55.0 vs 21.4 months) and overall survival (OS, 77.7 vs 35.8 months). Patients with high ICOS expression (46.5%) had longer median RFS (53.9 vs 25.3 months) and OS (88.8 vs 36.9 months). For PD-1, RFS (hazard ratio [HR] 0.67) and OS (HR 0.66) were significantly longer in the high-expression group (45.2%). In the multivariate analysis, high TIM-3 expression (50.8%) had a significant relationship with shorter RFS (HR = 1.52) and OS (HR = 1.60). High CD3+ TIL and T-cell ICOS expression were associated with favourable prognosis, whereas high TIM-3 expression suggested a poor prognosis. Our findings may confer new insights to improve ESCC outcomes beyond the application of PD-1 blockade.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherNature Publishing Group-
dc.relation.isPartOfSCIENTIFIC REPORTS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleHigh CD3 and ICOS and low TIM-3 expression predict favourable survival in resected oesophageal squamous cell carcinoma-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Thoracic and Cardiovascular Surgery (흉부외과학교실)-
dc.contributor.googleauthorMin Hee Hong-
dc.contributor.googleauthorSu-Jin Shin-
dc.contributor.googleauthorSung Kwan Shin-
dc.contributor.googleauthorDae Joon Kim-
dc.contributor.googleauthorJae Ill Zo-
dc.contributor.googleauthorYoung Mog Shim-
dc.contributor.googleauthorSeung Eun Lee-
dc.contributor.googleauthorByoung Chul Cho-
dc.contributor.googleauthorSeong Yong Park-
dc.contributor.googleauthorYoon-La Choi-
dc.contributor.googleauthorHye Ryun Kim-
dc.identifier.doi10.1038/s41598-019-56828-7-
dc.contributor.localIdA00368-
dc.contributor.localIdA01166-
dc.contributor.localIdA01166-
dc.contributor.localIdA01508-
dc.contributor.localIdA01508-
dc.contributor.localIdA02112-
dc.contributor.localIdA02112-
dc.contributor.localIdA04596-
dc.contributor.localIdA04596-
dc.contributor.localIdA03822-
dc.contributor.localIdA03822-
dc.contributor.localIdA04393-
dc.contributor.localIdA04393-
dc.relation.journalcodeJ02646-
dc.identifier.eissn2045-2322-
dc.identifier.pmid31882943-
dc.contributor.alternativeNameKim, Dae Joon-
dc.contributor.affiliatedAuthor김대준-
dc.contributor.affiliatedAuthor김혜련-
dc.contributor.affiliatedAuthor김혜련-
dc.contributor.affiliatedAuthor박성용-
dc.contributor.affiliatedAuthor박성용-
dc.contributor.affiliatedAuthor신성관-
dc.contributor.affiliatedAuthor신성관-
dc.contributor.affiliatedAuthor신수진-
dc.contributor.affiliatedAuthor신수진-
dc.contributor.affiliatedAuthor조병철-
dc.contributor.affiliatedAuthor조병철-
dc.contributor.affiliatedAuthor홍민희-
dc.contributor.affiliatedAuthor홍민희-
dc.citation.volume9-
dc.citation.number1-
dc.citation.startPage20197-
dc.identifier.bibliographicCitationSCIENTIFIC REPORTS, Vol.9(1) : 20197, 2019-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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