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Prognostic factors for unfavourable outcomes of patients with spinal tuberculosis in a country with an intermediate tuberculosis burden: a multicentre cohort study

DC Field Value Language
dc.contributor.author구남수-
dc.contributor.author김정호-
dc.contributor.author송영구-
dc.contributor.author안진영-
dc.contributor.author염준섭-
dc.contributor.author정수진-
dc.contributor.author최준용-
dc.date.accessioned2020-02-11T06:42:07Z-
dc.date.available2020-02-11T06:42:07Z-
dc.date.issued2019-
dc.identifier.issn2049-4394-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/174797-
dc.description.abstractAIMS: Spinal tuberculosis (TB) remains an important concern. Although spinal TB often has sequelae such as myelopathy after treatment, the predictive factors affecting such unfavourable outcomes are not yet established. We investigated the clinical manifestations and predictors of unfavourable treatment outcomes in patients with spinal TB. PATIENTS AND METHODS: We performed a multicentre retrospective cohort study of patients with spinal TB. Unfavourable outcome was defined according to previous studies. The prognostic factors for unfavourable outcomes as the primary outcome were determined using multivariable logistic regression analysis and a linear mixed model was used to compare time course of inflammatory markers during treatment. A total of 185 patients were included, of whom 59 patients had unfavourable outcomes. RESULTS: In multivariate regression analysis, the factors associated with unfavourable outcome were old age (odds ratio (OR) 2.51; 95% confidence interval (CI) 1.07 to 5.86; p = 0.034), acid-fast bacilli (AFB) smear positivity in specimens obtained through biopsy (OR 3.05; 95% CI 1.06 to 8.80; p = 0.039), and elevated erythrocyte sedimentation rate (ESR) at the end of treatment (OR 3.85; 95% CI 1.62 to 9.13; p = 0.002). Patients with unfavourable outcomes had a significant trend toward higher ESR during treatment compared with patients with favourable outcome (p = 0.009). Duration of anti-TB and surgical treatment did not affect prognosis. CONCLUSION: Elevated ESR at the end of treatment could be used as a marker to identify spinal TB patients with a poor prognosis. Patients whose ESR is not normalized during treatment, as well as those with old age and AFB smear positivity, should be aware of unfavourable outcomes.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherBritish Editorial Society of Bone & Joint Surgery-
dc.relation.isPartOfBONE & JOINT JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAntitubercular Agents/therapeutic use*-
dc.subject.MESHBiomarkers/blood-
dc.subject.MESHBlood Sedimentation-
dc.subject.MESHCombined Modality Therapy-
dc.subject.MESHCost of Illness-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHHumans-
dc.subject.MESHLinear Models-
dc.subject.MESHLogistic Models-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHOrthopedic Procedures*/methods-
dc.subject.MESHPrognosis-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHTuberculosis, Spinal/blood-
dc.subject.MESHTuberculosis, Spinal/diagnosis*-
dc.subject.MESHTuberculosis, Spinal/therapy*-
dc.titlePrognostic factors for unfavourable outcomes of patients with spinal tuberculosis in a country with an intermediate tuberculosis burden: a multicentre cohort study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorJung Ho Kim-
dc.contributor.googleauthorJin Young Ahn-
dc.contributor.googleauthorSu Jin Jeong-
dc.contributor.googleauthorNam Su Ku-
dc.contributor.googleauthorJun Yong Choi-
dc.contributor.googleauthorYoung Keun Kim-
dc.contributor.googleauthorJoon-Sup Yeom-
dc.contributor.googleauthorYoung Goo Song-
dc.identifier.doi10.1302/0301-620X.101B12.BJJ-2019-0558.R1-
dc.contributor.localIdA00189-
dc.contributor.localIdA00902-
dc.contributor.localIdA02037-
dc.contributor.localIdA02267-
dc.contributor.localIdA02353-
dc.contributor.localIdA03638-
dc.contributor.localIdA04191-
dc.relation.journalcodeJ00382-
dc.identifier.eissn2049-4408-
dc.identifier.pmid31786996-
dc.identifier.urlhttps://online.boneandjoint.org.uk/doi/full/10.1302/0301-620X.101B12.BJJ-2019-0558.R1-
dc.subject.keywordErythrocyte sedimentation rate-
dc.subject.keywordOutcome-
dc.subject.keywordPrognostic factor-
dc.subject.keywordSpinal tuberculosis-
dc.contributor.alternativeNameKu, Nam Su-
dc.contributor.affiliatedAuthor구남수-
dc.contributor.affiliatedAuthor김정호-
dc.contributor.affiliatedAuthor송영구-
dc.contributor.affiliatedAuthor안진영-
dc.contributor.affiliatedAuthor염준섭-
dc.contributor.affiliatedAuthor정수진-
dc.contributor.affiliatedAuthor최준용-
dc.citation.volume101-B-
dc.citation.number12-
dc.citation.startPage1542-
dc.citation.endPage1549-
dc.identifier.bibliographicCitationBONE & JOINT JOURNAL, Vol.101-B(12) : 1542-1549, 2019-
dc.identifier.rimsid63480-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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