Cited 39 times in
HERES, a lncRNA that regulates canonical and noncanonical Wnt signaling pathways via interaction with EZH2
DC Field | Value | Language |
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dc.contributor.author | 이상길 | - |
dc.date.accessioned | 2020-02-11T06:38:03Z | - |
dc.date.available | 2020-02-11T06:38:03Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/174761 | - |
dc.description.abstract | Wnt signaling through both canonical and noncanonical pathways plays a core role in development. Dysregulation of these pathways often causes cancer development and progression. Although the pathways independently contribute to the core processes, a regulatory molecule that commonly activates both of them has not yet been reported. Here, we describe a long noncoding RNA (lncRNA), HERES, that epigenetically regulates both canonical and noncanonical Wnt signaling pathways in esophageal squamous cell carcinoma (ESCC). For this study, we performed RNA-seq analysis on Korean ESCC patients and validated these results on a larger ESCC cohort to identify lncRNAs commonly dysregulated in ESCCs. Six of the dysregulated lncRNAs were significantly associated with the clinical outcomes of ESCC patients and defined 4 ESCC subclasses with different prognoses. HERES reduction repressed cell proliferation, migration, invasion, and colony formation in ESCC cell lines and tumor growth in xenograft models. HERES appears to be a transacting factor that regulates CACNA2D3, SFRP2, and CXXC4 simultaneously to activate Wnt signaling pathways through an interaction with EZH2 via its G-quadruple structure-like motif. Our results suggest that HERES holds substantial potential as a therapeutic target for ESCC and probably other cancers caused by defects in Wnt signaling pathways. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | National Academy of Sciences | - |
dc.relation.isPartOf | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | HERES, a lncRNA that regulates canonical and noncanonical Wnt signaling pathways via interaction with EZH2 | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Bo-Hyun You | - |
dc.contributor.googleauthor | Jung-Ho Yoon | - |
dc.contributor.googleauthor | Hoin Kang | - |
dc.contributor.googleauthor | Eun Kyung Lee | - |
dc.contributor.googleauthor | Sang Kil Lee | - |
dc.contributor.googleauthor | Jin-Wu Nam | - |
dc.identifier.doi | 10.1073/pnas.1912126116 | - |
dc.contributor.localId | A02812 | - |
dc.relation.journalcode | J02550 | - |
dc.identifier.eissn | 1091-6490 | - |
dc.identifier.pmid | 31732666 | - |
dc.subject.keyword | Wnt signaling pathway | - |
dc.subject.keyword | epigenetic regulation | - |
dc.subject.keyword | esophageal squamous cell carcinoma | - |
dc.subject.keyword | long noncoding RNA | - |
dc.contributor.alternativeName | Lee, Sang Kil | - |
dc.contributor.affiliatedAuthor | 이상길 | - |
dc.citation.volume | 116 | - |
dc.citation.number | 49 | - |
dc.citation.startPage | 24620 | - |
dc.citation.endPage | 24629 | - |
dc.identifier.bibliographicCitation | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol.116(49) : 24620-24629, 2019 | - |
dc.identifier.rimsid | 63421 | - |
dc.type.rims | ART | - |
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